Application of temperature sensitive yeast models with definite target in the screening of potential human Pin1 inhibitors

This study is to explore new lead compounds by inhibition of Pin1 for anticancer therapy using temperature sensitive mutants. As Pin1 is conserved from yeast to human, we established a high-throughput screening method for Pin1 inhibitors, which employed yeast assay. This method led to the identifica...

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Veröffentlicht in:	Yao hsüeh hsüeh pao 2014-06, Vol.49 (6), p.854-860
Hauptverfasser:	Zhang, Jing, Han, Xiao-Min, Hu, Wen-Hui, Guo, Zong-Ru, He, Xiao-Bo, Si, Shu-Yi
Format:	Artikel
Sprache:	chi
Schlagworte:	Animals Apoptosis - drug effects Cell Proliferation - drug effects Cyclin D1 - metabolism Drug Screening Assays, Antitumor - methods G1 Phase High-Throughput Screening Assays - methods Humans Mice Neoplasms - pathology NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase - antagonists & inhibitors Temperature Xenograft Model Antitumor Assays Yeasts
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