Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers
The receptor for hyaluronan (HA)-mediated motility (RHAMM) is a HA-binding protein located in the cytoskeleton and centrosome. RHAMM has multiple functions that manifest with different cellular localizations, for example, modulation of growth factor receptor, regulation of cell signaling pathways, a...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2014-10, Vol.140 (10), p.1629-1640 |
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| creator | Shigeishi, Hideo Higashikawa, Koichiro Takechi, Masaaki |
| description | The receptor for hyaluronan (HA)-mediated motility (RHAMM) is a HA-binding protein located in the cytoskeleton and centrosome. RHAMM has multiple functions that manifest with different cellular localizations, for example, modulation of growth factor receptor, regulation of cell signaling pathways, and mitotic spindle assembly. In addition, its increased expression has major roles in tumorigenesis and can induce genomic instability and cancer progression. In head and neck cancers, increased expression of RHAMM is associated with high proliferation of cancer cells and decreased survival. CD44, a cell-adhesion molecule and HA receptor, can modulate intracellular signaling by forming complexes with RHAMM to promote invasion and metastasis of cancer cells. In this review, we provide an overview of the biological functions of RHAMM in non-neoplastic cells and cancer cells, as well as its association with CD44, and also introduce studies that particularly implicate RHAMM in the pathogenesis of head and neck cancers. |
| doi_str_mv | 10.1007/s00432-014-1653-z |
| format | Article |
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RHAMM has multiple functions that manifest with different cellular localizations, for example, modulation of growth factor receptor, regulation of cell signaling pathways, and mitotic spindle assembly. In addition, its increased expression has major roles in tumorigenesis and can induce genomic instability and cancer progression. In head and neck cancers, increased expression of RHAMM is associated with high proliferation of cancer cells and decreased survival. CD44, a cell-adhesion molecule and HA receptor, can modulate intracellular signaling by forming complexes with RHAMM to promote invasion and metastasis of cancer cells. In this review, we provide an overview of the biological functions of RHAMM in non-neoplastic cells and cancer cells, as well as its association with CD44, and also introduce studies that particularly implicate RHAMM in the pathogenesis of head and neck cancers.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-014-1653-z</identifier><identifier>PMID: 24676428</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer Research ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell Movement ; Cell Proliferation ; Centrosome ; Cytoskeleton ; Disease Progression ; Extracellular Matrix Proteins - metabolism ; Fluorescent Antibody Technique ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - physiopathology ; Hematology ; Humans ; Hyaluronan Receptors - metabolism ; Hyaluronic Acid - metabolism ; Internal Medicine ; MAP Kinase Signaling System ; Medicine ; Medicine & Public Health ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - metabolism ; Neoplasm Invasiveness ; Neoplasms - metabolism ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Oncology ; Review – Cancer Research ; Signal Transduction</subject><ispartof>Journal of cancer research and clinical oncology, 2014-10, Vol.140 (10), p.1629-1640</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-8c621fbff8fba9a0396130933d219d55beb48483ce3161b120e9d6ed46f88a5b3</citedby><cites>FETCH-LOGICAL-c480t-8c621fbff8fba9a0396130933d219d55beb48483ce3161b120e9d6ed46f88a5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-014-1653-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-014-1653-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24676428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shigeishi, Hideo</creatorcontrib><creatorcontrib>Higashikawa, Koichiro</creatorcontrib><creatorcontrib>Takechi, Masaaki</creatorcontrib><title>Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>The receptor for hyaluronan (HA)-mediated motility (RHAMM) is a HA-binding protein located in the cytoskeleton and centrosome. RHAMM has multiple functions that manifest with different cellular localizations, for example, modulation of growth factor receptor, regulation of cell signaling pathways, and mitotic spindle assembly. In addition, its increased expression has major roles in tumorigenesis and can induce genomic instability and cancer progression. In head and neck cancers, increased expression of RHAMM is associated with high proliferation of cancer cells and decreased survival. CD44, a cell-adhesion molecule and HA receptor, can modulate intracellular signaling by forming complexes with RHAMM to promote invasion and metastasis of cancer cells. In this review, we provide an overview of the biological functions of RHAMM in non-neoplastic cells and cancer cells, as well as its association with CD44, and also introduce studies that particularly implicate RHAMM in the pathogenesis of head and neck cancers.</description><subject>Cancer Research</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Centrosome</subject><subject>Cytoskeleton</subject><subject>Disease Progression</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - physiopathology</subject><subject>Hematology</subject><subject>Humans</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Hyaluronic Acid - metabolism</subject><subject>Internal Medicine</subject><subject>MAP Kinase Signaling System</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasms - metabolism</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Oncology</subject><subject>Review – Cancer Research</subject><subject>Signal Transduction</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AC-Sox6qmaTNpkcRv0ARRMFbSNOJVttkTdrD-uvNsurRw8wwM--8MA8hh8BOgbH5WWKsFLxgUBYgK1F8bZAZrCYgRLVJZgzmUFQc5A7ZTemd5b6a822yw0s5lyVXM_LyGHqkwdGIFhdjiNTleFuaforBG18M2HZmxJYOYez6blzS48eb8_v7E9p5-jYNJmc0LTW-pR7tB7XGW4xpn2w50yc8-Kl75Pnq8uniprh7uL69OL8rbKnYWCgrObjGOeUaUxsmagmC1UK0HOq2qhpsSlUqYVGAhAY4w7qV2JbSKWWqRuyR47XvIobPCdOohy5Z7HvjMUxJQyWhlooJkaWwltoYUoro9CJ2g4lLDUyvgOo1UJ2B6hVQ_ZVvjn7spyaj-Lv4JZgFfC1IeeVfMer3MEWfX_7H9RtpcoBV</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Shigeishi, Hideo</creator><creator>Higashikawa, Koichiro</creator><creator>Takechi, Masaaki</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers</title><author>Shigeishi, Hideo ; Higashikawa, Koichiro ; Takechi, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-8c621fbff8fba9a0396130933d219d55beb48483ce3161b120e9d6ed46f88a5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cancer Research</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Centrosome</topic><topic>Cytoskeleton</topic><topic>Disease Progression</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Fluorescent Antibody Technique</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - physiopathology</topic><topic>Hematology</topic><topic>Humans</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Hyaluronic Acid - metabolism</topic><topic>Internal Medicine</topic><topic>MAP Kinase Signaling System</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasms - metabolism</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Oncology</topic><topic>Review – Cancer Research</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shigeishi, Hideo</creatorcontrib><creatorcontrib>Higashikawa, Koichiro</creatorcontrib><creatorcontrib>Takechi, Masaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shigeishi, Hideo</au><au>Higashikawa, Koichiro</au><au>Takechi, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>140</volume><issue>10</issue><spage>1629</spage><epage>1640</epage><pages>1629-1640</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>The receptor for hyaluronan (HA)-mediated motility (RHAMM) is a HA-binding protein located in the cytoskeleton and centrosome. 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| subjects | Cancer Research Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Movement Cell Proliferation Centrosome Cytoskeleton Disease Progression Extracellular Matrix Proteins - metabolism Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Head and Neck Neoplasms - physiopathology Hematology Humans Hyaluronan Receptors - metabolism Hyaluronic Acid - metabolism Internal Medicine MAP Kinase Signaling System Medicine Medicine & Public Health Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neoplasm Invasiveness Neoplasms - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncology Review – Cancer Research Signal Transduction |
| title | Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers |
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