Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia

A series of 6-acylureido derivatives containing a 3-(pyrrol-2-ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2-one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-10, Vol.85, p.268-288
Hauptverfasser:	Jagtap, Ajit Dhananjay, Chang, Pei-Teh, Liu, Jia-Rong, Wang, Hsiao-Chun, Kondekar, Nagendra B., Shen, Li-Jiuan, Tseng, Hsiang-Wen, Chen, Grace Shiahuy, Chern, Ji-Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyluriedoindolin-2-one Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Aurora B Aurora Kinase B - antagonists & inhibitors Cell Line, Tumor Cercopithecus aethiops Drug Design FLT-3 fms-Like Tyrosine Kinase 3 - antagonists & inhibitors Humans Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Indoles - therapeutic use Inhibitors Leukemia Leukemia, Myeloid, Acute - drug therapy Male Mice Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Structure–activity relationship Vero Cells Xenograft Model Antitumor Assays
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