Long-Term High-Dose Vitamin D3 Supplementation and Blood Pressure in Healthy Adults: A Randomized Controlled Trial
Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (100 nmol/L for 18 months, had no effect on systolic or diastolic BP in predominantly white, healthy adults without severe vitamin D deficiency. Beneficial effects...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-10, Vol.64 (4), p.725-730 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 64 |
| creator | Scragg, Robert Slow, Sandy Stewart, Alistair W Jennings, Lance C Chambers, Stephen T Priest, Patricia C Florkowski, Christopher M Camargo, Carlos A Murdoch, David R |
| description | Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (100 nmol/L for 18 months, had no effect on systolic or diastolic BP in predominantly white, healthy adults without severe vitamin D deficiency. Beneficial effects on BP cannot be ruled out for other populations. |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.114.03466 |
| format | Article |
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This study aims to determine whether long-term high-dose vitamin D taken for 18 months lowers BP. Adults were recruited from a healthcare organization or university into a double-blind controlled trial and randomized to receive either vitamin D3 200 000 IU for 2 months followed by 100 000 IU monthly up to 18 months (n=161) or placebo (n=161). BP was measured at baseline, 5, and 18 months. Subjects had a mean (SD) age of 47.6 (9.7) years, 75% were women, and 94% were of European ancestry (white). Mean (SD) 25-hydroxyvitamin D3 changed from 73 (22) nmol/L at baseline to 124 (28) nmol/L at 18 months in the vitamin D group, and from 71 (22) nmol/L to 56 (22) nmol/L in the placebo group. Mean BP was similar for the vitamin D and placebo groups at baseline (123.4/76.3 versus 122.6/75.6 mm Hg; respectively). The mean change (95% confidence interval) in BP at 18 months minus baseline in the vitamin D group compared with placebo group was −0.6 (−2.8 to 1.6) mm Hg for systolic (P=0.61) and 0.5 (−1.1, 2.2) mm Hg for diastolic (P=0.53). Long-term vitamin D supplementation, which increased mean 25-hydroxyvitamin D3 concentration >100 nmol/L for 18 months, had no effect on systolic or diastolic BP in predominantly white, healthy adults without severe vitamin D deficiency. Beneficial effects on BP cannot be ruled out for other populations.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.114.03466</identifier><identifier>PMID: 24980662</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cholecalciferol - administration & dosage ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Time Factors ; Treatment Outcome ; Vitamins - administration & dosage ; Young Adult</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2014-10, Vol.64 (4), p.725-730</ispartof><rights>2014 American Heart Association, Inc</rights><rights>2014 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24980662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scragg, Robert</creatorcontrib><creatorcontrib>Slow, Sandy</creatorcontrib><creatorcontrib>Stewart, Alistair W</creatorcontrib><creatorcontrib>Jennings, Lance C</creatorcontrib><creatorcontrib>Chambers, Stephen T</creatorcontrib><creatorcontrib>Priest, Patricia C</creatorcontrib><creatorcontrib>Florkowski, Christopher M</creatorcontrib><creatorcontrib>Camargo, Carlos A</creatorcontrib><creatorcontrib>Murdoch, David R</creatorcontrib><title>Long-Term High-Dose Vitamin D3 Supplementation and Blood Pressure in Healthy Adults: A Randomized Controlled Trial</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (<6 months) or at low doses (400 IU per day). This study aims to determine whether long-term high-dose vitamin D taken for 18 months lowers BP. Adults were recruited from a healthcare organization or university into a double-blind controlled trial and randomized to receive either vitamin D3 200 000 IU for 2 months followed by 100 000 IU monthly up to 18 months (n=161) or placebo (n=161). BP was measured at baseline, 5, and 18 months. Subjects had a mean (SD) age of 47.6 (9.7) years, 75% were women, and 94% were of European ancestry (white). Mean (SD) 25-hydroxyvitamin D3 changed from 73 (22) nmol/L at baseline to 124 (28) nmol/L at 18 months in the vitamin D group, and from 71 (22) nmol/L to 56 (22) nmol/L in the placebo group. Mean BP was similar for the vitamin D and placebo groups at baseline (123.4/76.3 versus 122.6/75.6 mm Hg; respectively). The mean change (95% confidence interval) in BP at 18 months minus baseline in the vitamin D group compared with placebo group was −0.6 (−2.8 to 1.6) mm Hg for systolic (P=0.61) and 0.5 (−1.1, 2.2) mm Hg for diastolic (P=0.53). Long-term vitamin D supplementation, which increased mean 25-hydroxyvitamin D3 concentration >100 nmol/L for 18 months, had no effect on systolic or diastolic BP in predominantly white, healthy adults without severe vitamin D deficiency. Beneficial effects on BP cannot be ruled out for other populations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vitamins - administration & dosage</subject><subject>Young Adult</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kN1O3DAQha2KqmxpXwGZO24MnthxYu7Csm2QVoBgW7VXkTeZsAEnDnYiRJ--ptCRRvP3aaRzCDkCfgKg4LT8fbO63ayu7i6vr4qyiEt5woVU6gNZQJpIJlMl9siCg5ZMA_zaJ59DeOAcpJTZJ7KfSJ1zpZIF8Ws33LMN-p6W3f2OXbiA9Gc3mb4b6IWgd_M4WuxxmMzUuYGaoaHn1rmG3ngMYfZII1iisdPuhRbNbKdwRgt6G0HXd3-woUs3TN5ZG9uN74z9Qj62xgb8-l4PyI9vq82yZOvr75fLYs3GRAJndZoLsxU11hy3W4FpDqqNl1zntYgCsgxaDUa2MuUJl5iKBoVqMdN1q9O2FQfk-O3v6N3TjGGq-i7UaK0Z0M2hglSBVpnQSUQP39F522NTjb7rjX-p_vsUAfkGPDs7oQ-Pdn5GX-3-6a54DJmonCXRYXidWEzg4i_sZnyE</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Scragg, Robert</creator><creator>Slow, Sandy</creator><creator>Stewart, Alistair W</creator><creator>Jennings, Lance C</creator><creator>Chambers, Stephen T</creator><creator>Priest, Patricia C</creator><creator>Florkowski, Christopher M</creator><creator>Camargo, Carlos A</creator><creator>Murdoch, David R</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Long-Term High-Dose Vitamin D3 Supplementation and Blood Pressure in Healthy Adults: A Randomized Controlled Trial</title><author>Scragg, Robert ; Slow, Sandy ; Stewart, Alistair W ; Jennings, Lance C ; Chambers, Stephen T ; Priest, Patricia C ; Florkowski, Christopher M ; Camargo, Carlos A ; Murdoch, David R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2410-c583ab3cec0ebb3e5816f241898c3249771f91a4f450204e53de36fe79cf95ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vitamins - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scragg, Robert</creatorcontrib><creatorcontrib>Slow, Sandy</creatorcontrib><creatorcontrib>Stewart, Alistair W</creatorcontrib><creatorcontrib>Jennings, Lance C</creatorcontrib><creatorcontrib>Chambers, Stephen T</creatorcontrib><creatorcontrib>Priest, Patricia C</creatorcontrib><creatorcontrib>Florkowski, Christopher M</creatorcontrib><creatorcontrib>Camargo, Carlos A</creatorcontrib><creatorcontrib>Murdoch, David R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scragg, Robert</au><au>Slow, Sandy</au><au>Stewart, Alistair W</au><au>Jennings, Lance C</au><au>Chambers, Stephen T</au><au>Priest, Patricia C</au><au>Florkowski, Christopher M</au><au>Camargo, Carlos A</au><au>Murdoch, David R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term High-Dose Vitamin D3 Supplementation and Blood Pressure in Healthy Adults: A Randomized Controlled Trial</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2014-10</date><risdate>2014</risdate><volume>64</volume><issue>4</issue><spage>725</spage><epage>730</epage><pages>725-730</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><abstract>Previous randomized controlled trials of vitamin D supplementation and blood pressure (BP) mainly have given vitamin D for short periods (<6 months) or at low doses (400 IU per day). This study aims to determine whether long-term high-dose vitamin D taken for 18 months lowers BP. Adults were recruited from a healthcare organization or university into a double-blind controlled trial and randomized to receive either vitamin D3 200 000 IU for 2 months followed by 100 000 IU monthly up to 18 months (n=161) or placebo (n=161). BP was measured at baseline, 5, and 18 months. Subjects had a mean (SD) age of 47.6 (9.7) years, 75% were women, and 94% were of European ancestry (white). Mean (SD) 25-hydroxyvitamin D3 changed from 73 (22) nmol/L at baseline to 124 (28) nmol/L at 18 months in the vitamin D group, and from 71 (22) nmol/L to 56 (22) nmol/L in the placebo group. Mean BP was similar for the vitamin D and placebo groups at baseline (123.4/76.3 versus 122.6/75.6 mm Hg; respectively). The mean change (95% confidence interval) in BP at 18 months minus baseline in the vitamin D group compared with placebo group was −0.6 (−2.8 to 1.6) mm Hg for systolic (P=0.61) and 0.5 (−1.1, 2.2) mm Hg for diastolic (P=0.53). Long-term vitamin D supplementation, which increased mean 25-hydroxyvitamin D3 concentration >100 nmol/L for 18 months, had no effect on systolic or diastolic BP in predominantly white, healthy adults without severe vitamin D deficiency. Beneficial effects on BP cannot be ruled out for other populations.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>24980662</pmid><doi>10.1161/HYPERTENSIONAHA.114.03466</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Blood Pressure - drug effects Blood Pressure - physiology Cholecalciferol - administration & dosage Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Middle Aged Time Factors Treatment Outcome Vitamins - administration & dosage Young Adult |
| title | Long-Term High-Dose Vitamin D3 Supplementation and Blood Pressure in Healthy Adults: A Randomized Controlled Trial |
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