Binding of 4',6-diamidino-2-phenylindole (DAPI) to GC and mixed sequences in DNA: Intercalation of a classical groove-binding molecule

Binding of 4',6-diamidino-2-phenylindole (DAPI) to GC and mixed sequences in DNA: Intercalation of a classical groove-binding molecule

DNA intercalators typically contain planar, fused-aromatic systems that slide between base pairs in the complex. Molecules that bind in the minor groove generally contain unfused-aromatic systems with terminal basic functions. The intercalation with DNA of a group of unfused-aromatic cations, simila...

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Veröffentlicht in:Journal of the American Chemical Society 1989-06, Vol.111 (13), p.5008-5010
Hauptverfasser: Wilson, W D, Tanious, F A, Barton, HJ, Strekowski, L, Boykin, D W, Jones, R L
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container_end_page 5010
container_issue 13
container_start_page 5008
container_title Journal of the American Chemical Society
container_volume 111
creator Wilson, W D
Tanious, F A
Barton, HJ
Strekowski, L
Boykin, D W
Jones, R L
description DNA intercalators typically contain planar, fused-aromatic systems that slide between base pairs in the complex. Molecules that bind in the minor groove generally contain unfused-aromatic systems with terminal basic functions. The intercalation with DNA of a group of unfused-aromatic cations, similar in structure to classical groove-binding molecules, has led to the conclusion that intercalation and groove-binding modes should be viewed as two variable depth potential wells on a continuous energy surface.
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title Binding of 4',6-diamidino-2-phenylindole (DAPI) to GC and mixed sequences in DNA: Intercalation of a classical groove-binding molecule
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