Favorable interaction of β- l(−) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus

The combination of l(−)-2-′,3′-dideoxy-3′-thiacytidine ( l(−)SddC, 3TC), l(−)-2′,3′-dideoxy-5-fluorocytidine ( l(−)FddC), or l(−)-2′,3′-dideoxy-5-fluoro-3′-thiacytidine ( l(−)FTC) with 3′-azido-3′-deoxythymidine (AZT) synergistically inhibited replication of human immunodeficiency virus (HIV) in vit...

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