Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory growth in yeast and mammalian embryonic survival. The human 3-ketoacyl-acyl carrier protein (ACP) reductase (KAR) of mtFAS is a heterotetrameric α 2 β 2 -assembly composed of 17β-hydroxysteroid dehydrogenase type-8 (HSD17B8, α-s...

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Veröffentlicht in:	Nature communications 2014-09, Vol.5 (1), p.4805-4805, Article 4805
Hauptverfasser:	Venkatesan, Rajaram, Sah-Teli, Shiv K., Awoniyi, Luqman O., Jiang, Guangyu, Prus, Piotr, Kastaniotis, Alexander J., Hiltunen, J. Kalervo, Wierenga, Rik K., Chen, Zhijun
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxyacyl CoA Dehydrogenases - metabolism 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase - metabolism 38/23 38/70 38/77 631/443/319 631/45/287/1183 631/45/535 82/103 82/16 82/29 82/80 82/83 Bacterial Proteins - metabolism Catalysis Crystal structure Crystallography, X-Ray Data collection Dehydrogenases Enzyme Assays Enzymes Escherichia coli Proteins - metabolism Fatty acids Fatty Acids - biosynthesis Humanities and Social Sciences Humans Metabolism Metabolites Mitochondria - metabolism Mitochondrial Proteins - metabolism multidisciplinary Mycobacterium tuberculosis - metabolism NAD(P)H Dehydrogenase (Quinone) - metabolism Oxidation Oxidoreductases - metabolism Physiology Protein Structure, Quaternary Proteins Proteins - metabolism Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary)
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