Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer

Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally...

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Veröffentlicht in:	Nano letters 2014-09, Vol.14 (9), p.5458-5470
Hauptverfasser:	Faria, Paula Cristina Batista de, Santos, Luara Isabela dos, Coelho, João Paulo, Ribeiro, Henrique Bücker, Pimenta, Marcos Assunção, Ladeira, Luiz Orlando, Gomes, Dawidson Assis, Furtado, Clascídia Aparecida, Gazzinelli, Ricardo Tostes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - chemistry Antigens - chemistry Antigens, Neoplasm - chemistry Calibration Cancer Vaccines - chemistry CD4-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - cytology Cell Proliferation CpG Islands Dendritic Cells - drug effects Female Flow Cytometry Humans Lymphocytes - cytology Membrane Proteins - chemistry Mice Mice, Inbred BALB C Mice, Inbred C57BL Microscopy, Electron, Transmission Nanotechnology - methods Nanotubes, Carbon - chemistry Neoplasms - metabolism Neoplasms - prevention & control Neoplasms - therapy Oxygen - chemistry Peptides - chemistry Spectrum Analysis, Raman
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