Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer
Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally...
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| Veröffentlicht in: | Nano letters 2014-09, Vol.14 (9), p.5458-5470 |
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| creator | Faria, Paula Cristina Batista de Santos, Luara Isabela dos Coelho, João Paulo Ribeiro, Henrique Bücker Pimenta, Marcos Assunção Ladeira, Luiz Orlando Gomes, Dawidson Assis Furtado, Clascídia Aparecida Gazzinelli, Ricardo Tostes |
| description | Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally synthetic hybrid supramolecule as an anticancer vaccine formulation. This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. The CNT constructs were rapidly internalized into dendritic cells, both in vitro and in vivo, and served as an intracellular antigen depot. This property favored the induction of strong CD4+ T as well as CD8+ T cell-mediated immune responses against the NY-ESO-1. Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer. |
| doi_str_mv | 10.1021/nl502911a |
| format | Article |
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Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer.</description><identifier>ISSN: 1530-6984</identifier><identifier>EISSN: 1530-6992</identifier><identifier>DOI: 10.1021/nl502911a</identifier><identifier>PMID: 25115645</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Anticarcinogenic Agents - chemistry ; Antigens - chemistry ; Antigens, Neoplasm - chemistry ; Calibration ; Cancer Vaccines - chemistry ; CD4-Positive T-Lymphocytes - cytology ; CD8-Positive T-Lymphocytes - cytology ; Cell Proliferation ; CpG Islands ; Dendritic Cells - drug effects ; Female ; Flow Cytometry ; Humans ; Lymphocytes - cytology ; Membrane Proteins - chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Microscopy, Electron, Transmission ; Nanotechnology - methods ; Nanotubes, Carbon - chemistry ; Neoplasms - metabolism ; Neoplasms - prevention & control ; Neoplasms - therapy ; Oxygen - chemistry ; Peptides - chemistry ; Spectrum Analysis, Raman</subject><ispartof>Nano letters, 2014-09, Vol.14 (9), p.5458-5470</ispartof><rights>Copyright © 2014 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a315t-f3334ee5fb1ff0e78b3bb3340937f121a9ff20b4db5363f464e49fd95b13b94e3</citedby><cites>FETCH-LOGICAL-a315t-f3334ee5fb1ff0e78b3bb3340937f121a9ff20b4db5363f464e49fd95b13b94e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/nl502911a$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/nl502911a$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25115645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faria, Paula Cristina Batista de</creatorcontrib><creatorcontrib>Santos, Luara Isabela dos</creatorcontrib><creatorcontrib>Coelho, João Paulo</creatorcontrib><creatorcontrib>Ribeiro, Henrique Bücker</creatorcontrib><creatorcontrib>Pimenta, Marcos Assunção</creatorcontrib><creatorcontrib>Ladeira, Luiz Orlando</creatorcontrib><creatorcontrib>Gomes, Dawidson Assis</creatorcontrib><creatorcontrib>Furtado, Clascídia Aparecida</creatorcontrib><creatorcontrib>Gazzinelli, Ricardo Tostes</creatorcontrib><title>Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally synthetic hybrid supramolecule as an anticancer vaccine formulation. This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. The CNT constructs were rapidly internalized into dendritic cells, both in vitro and in vivo, and served as an intracellular antigen depot. This property favored the induction of strong CD4+ T as well as CD8+ T cell-mediated immune responses against the NY-ESO-1. Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - chemistry</subject><subject>Antigens - chemistry</subject><subject>Antigens, Neoplasm - chemistry</subject><subject>Calibration</subject><subject>Cancer Vaccines - chemistry</subject><subject>CD4-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>Cell Proliferation</subject><subject>CpG Islands</subject><subject>Dendritic Cells - drug effects</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Lymphocytes - cytology</subject><subject>Membrane Proteins - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nanotechnology - methods</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - prevention & control</subject><subject>Neoplasms - therapy</subject><subject>Oxygen - chemistry</subject><subject>Peptides - chemistry</subject><subject>Spectrum Analysis, Raman</subject><issn>1530-6984</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtKBDEQRYMovhf-gGQjKDKadJJ2spT2Cb7wsW6S7opEupMxSavjD_jbRkZn5aouxeFW3YvQFiUHlBT00HWCFJJStYBWqWBkVEpZLM71mK-gtRhfCCGSCbKMVgpBqSi5WEVftx-2tZ_Q4uuhS_ZddV3WlQraO3yjnE-DhohVxMcu2Wdw-AQ6-wZhih-mMUGPk8d3wfc-AX4YJhCsD7g6Ge_jR1xB1-F7iBPvImDl2h8yQZNsNlfPyrqY8i3XQNhAS0Z1ETZ_5zp6Ojt9rC5GV7fnl9Xx1UgxKtLIMMY4gDCaGkPgaKyZ1nmVgx0ZWlAljSmI5q0WrGSGlxy4NK0UmjItObB1tDvznQT_OkBMdW9jk_9UDvwQ61wL5aXgkmV0b4Y2wccYwNSTYHsVpjUl9U_v9bz3zG7_2g66h3ZO_hWdgZ0ZoJpYv_ghuJzyH6NvIK-Kbw</recordid><startdate>20140910</startdate><enddate>20140910</enddate><creator>Faria, Paula Cristina Batista de</creator><creator>Santos, Luara Isabela dos</creator><creator>Coelho, João Paulo</creator><creator>Ribeiro, Henrique Bücker</creator><creator>Pimenta, Marcos Assunção</creator><creator>Ladeira, Luiz Orlando</creator><creator>Gomes, Dawidson Assis</creator><creator>Furtado, Clascídia Aparecida</creator><creator>Gazzinelli, Ricardo Tostes</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140910</creationdate><title>Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer</title><author>Faria, Paula Cristina Batista de ; Santos, Luara Isabela dos ; Coelho, João Paulo ; Ribeiro, Henrique Bücker ; Pimenta, Marcos Assunção ; Ladeira, Luiz Orlando ; Gomes, Dawidson Assis ; Furtado, Clascídia Aparecida ; Gazzinelli, Ricardo Tostes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a315t-f3334ee5fb1ff0e78b3bb3340937f121a9ff20b4db5363f464e49fd95b13b94e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - chemistry</topic><topic>Antigens - chemistry</topic><topic>Antigens, Neoplasm - chemistry</topic><topic>Calibration</topic><topic>Cancer Vaccines - chemistry</topic><topic>CD4-Positive T-Lymphocytes - cytology</topic><topic>CD8-Positive T-Lymphocytes - cytology</topic><topic>Cell Proliferation</topic><topic>CpG Islands</topic><topic>Dendritic Cells - drug effects</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Lymphocytes - cytology</topic><topic>Membrane Proteins - chemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nanotechnology - methods</topic><topic>Nanotubes, Carbon - chemistry</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - prevention & control</topic><topic>Neoplasms - therapy</topic><topic>Oxygen - chemistry</topic><topic>Peptides - chemistry</topic><topic>Spectrum Analysis, Raman</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faria, Paula Cristina Batista de</creatorcontrib><creatorcontrib>Santos, Luara Isabela dos</creatorcontrib><creatorcontrib>Coelho, João Paulo</creatorcontrib><creatorcontrib>Ribeiro, Henrique Bücker</creatorcontrib><creatorcontrib>Pimenta, Marcos Assunção</creatorcontrib><creatorcontrib>Ladeira, Luiz Orlando</creatorcontrib><creatorcontrib>Gomes, Dawidson Assis</creatorcontrib><creatorcontrib>Furtado, Clascídia Aparecida</creatorcontrib><creatorcontrib>Gazzinelli, Ricardo Tostes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nano letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faria, Paula Cristina Batista de</au><au>Santos, Luara Isabela dos</au><au>Coelho, João Paulo</au><au>Ribeiro, Henrique Bücker</au><au>Pimenta, Marcos Assunção</au><au>Ladeira, Luiz Orlando</au><au>Gomes, Dawidson Assis</au><au>Furtado, Clascídia Aparecida</au><au>Gazzinelli, Ricardo Tostes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2014-09-10</date><risdate>2014</risdate><volume>14</volume><issue>9</issue><spage>5458</spage><epage>5470</epage><pages>5458-5470</pages><issn>1530-6984</issn><eissn>1530-6992</eissn><abstract>Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally synthetic hybrid supramolecule as an anticancer vaccine formulation. This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. The CNT constructs were rapidly internalized into dendritic cells, both in vitro and in vivo, and served as an intracellular antigen depot. This property favored the induction of strong CD4+ T as well as CD8+ T cell-mediated immune responses against the NY-ESO-1. Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>25115645</pmid><doi>10.1021/nl502911a</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Anticarcinogenic Agents - chemistry Antigens - chemistry Antigens, Neoplasm - chemistry Calibration Cancer Vaccines - chemistry CD4-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - cytology Cell Proliferation CpG Islands Dendritic Cells - drug effects Female Flow Cytometry Humans Lymphocytes - cytology Membrane Proteins - chemistry Mice Mice, Inbred BALB C Mice, Inbred C57BL Microscopy, Electron, Transmission Nanotechnology - methods Nanotubes, Carbon - chemistry Neoplasms - metabolism Neoplasms - prevention & control Neoplasms - therapy Oxygen - chemistry Peptides - chemistry Spectrum Analysis, Raman |
| title | Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer |
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