Cisplatin microcrystals suspended in oil—toxicity in mice

A new dosage format, cisplatin microcrystals suspended in oil (CDDP-oil), was developed for the treatment of peritoneal carcinomatoses. We studied the acute toxicity of CDDP-oil injected intraperitoneally in mice. The 50% lethal dose was 30.3 mg/kg (27.1–33.7 mg/kg at the 95% confidence level), whic...

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Veröffentlicht in:	Anti-cancer drugs 1993-06, Vol.4 (3), p.377-380
Hauptverfasser:	Tsujimoto, Hiroyuki, Hagiwara, Akeo, Sakakura, Chouhei, Sasaki, Sadayuki, Osaki, Kimihiko, Ohyama, Takayuki, Sakakibara, Tsuguo, Takahashi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Chemistry, Pharmaceutical Cisplatin - administration & dosage Cisplatin - toxicity Crystallization Iodized Oil Lethal Dose 50 Male Mice Mice, Inbred Strains Sesame Oil Suspensions Weight Loss - drug effects
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