In-vitro activity of azithromycin against Chlamydia trachomatis

In-vitro activity of azithromycin against Chlamydia trachomatis

We evaluated the efficacy of azithromycin, erythromycin and doxycycline in controlling in-vitro propagation of Chlamydia trachomatis in HeLa 229 cells. Eight recent clinical isolates of C. trachomatis and two fast-growing strains were tested with inocula of 10 super(3)-10 super(5) inclusion forming...

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Hauptverfasser: Scieux, C, Bianchi, A, Chappey, B, Vassias, I, Perol, Y
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Bianchi, A
Chappey, B
Vassias, I
Perol, Y
description We evaluated the efficacy of azithromycin, erythromycin and doxycycline in controlling in-vitro propagation of Chlamydia trachomatis in HeLa 229 cells. Eight recent clinical isolates of C. trachomatis and two fast-growing strains were tested with inocula of 10 super(3)-10 super(5) inclusion forming units per well of a 96-well microtitre plate. C. trachomatis) inclusions were detected by an immunoperoxidase-antiperoxidase procedure (PAP), including a genus-specific monoclonal antibody. MIC ranges were 0 multiplied by 064-0 multiplied by 25 mg/l azithromycin, 0 multiplied by 064-0 multiplied by 128 mg/l erythromycin and 0 multiplied by 016-0 multiplied by 064 mg/l doxycyline; MBC ranges were 2-8 mg/l azithromycin, 4-64 mg/l erythromycin and 0 multiplied by 5-8 mg/l doxycycline. Since azithromycin appears to be effective against C. trachomatis , clinical studies in sexually transmitted diseases are indicated.
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Since azithromycin appears to be effective against C. trachomatis , clinical studies in sexually transmitted diseases are indicated.</abstract></addata></record>
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title In-vitro activity of azithromycin against Chlamydia trachomatis
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