The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis

Background and Objective It has been demonstrated that periodontitis induces systemic inflammation, which may impair endothelial function leading to increased cardiovascular risk. The aim of this study was to evaluate the effect of simvastatin on systemic inflammatory markers and endothelial dysfunc...

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Veröffentlicht in:	Journal of periodontal research 2014-10, Vol.49 (5), p.634-641
Hauptverfasser:	Machado, W. M., Prestes, A. P., Costa, T. P., Mendes, R. T., Olchanheski Jr, L. R., Sordi, R., Otuki, M. F., Fávero, G. M., Vellosa, J. C. R., Santos, F. A., Fernandes, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - therapeutic use Alveolar Bone Loss - immunology Alveolar Bone Loss - prevention & control Animals Arterial Pressure - drug effects C-Reactive Protein - analysis C-Reactive Protein - drug effects Dentistry Disease Models, Animal endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Inflammation Mediators - immunology Interleukin-6 - blood Leukocyte Count Lipids - blood Male Nitroprusside - therapeutic use periodontitis Periodontitis - immunology Periodontitis - prevention & control Random Allocation Rats Rats, Wistar simvastatin Simvastatin - therapeutic use systemic inflammation Vasodilator Agents - therapeutic use
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