microRNA-7: A tumor suppressor miRNA with therapeutic potential
microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, splee...
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| Veröffentlicht in: | The international journal of biochemistry & cell biology 2014-09, Vol.54, p.312-317 |
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| container_title | The international journal of biochemistry & cell biology |
| container_volume | 54 |
| creator | Kalinowski, Felicity C. Brown, Rikki A.M. Ganda, Clarissa Giles, Keith M. Epis, Michael R. Horsham, Jessica Leedman, Peter J. |
| description | microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 (‘miRNA replacement therapy’) for specific human cancers could represent a new treatment approach.
This article is part of a Directed Issue entitled: The Non-coding RNA Revolution. |
| doi_str_mv | 10.1016/j.biocel.2014.05.040 |
| format | Article |
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| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cancer Epidermal growth factor receptor Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Humans microRNA-7 MicroRNAs - genetics Neoplasms - genetics Neoplasms - therapy Tumor suppressor |
| title | microRNA-7: A tumor suppressor miRNA with therapeutic potential |
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