The Electrode-Tissue Interface: The Revolutionary Role of Steroid-Elution
The electrode‐tissue interface is that area lying between the cathode of a low‐voltage implantable pacemaker or cardioverter‐defibrillator (ICD) lead and the endocardium or epi‐myocardium of the cardiac chamber being paced. The electrical stimulus that is delivered to this interface is responsible f...
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| Veröffentlicht in: | Pacing and clinical electrophysiology 2014-09, Vol.37 (9), p.1232-1249 |
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| container_title | Pacing and clinical electrophysiology |
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| creator | MOND, HARRY G. HELLAND, JOHN R. STOKES, KENNETH BORNZIN, GENE A. McVENES, RICK |
| description | The electrode‐tissue interface is that area lying between the cathode of a low‐voltage implantable pacemaker or cardioverter‐defibrillator (ICD) lead and the endocardium or epi‐myocardium of the cardiac chamber being paced. The electrical stimulus that is delivered to this interface is responsible for myocyte depolarization with consequent cardiac contraction. The process by which this occurs is reasonably well understood and any explanation requires a basic understanding of the physics and cellular electrophysiology of pacing. The effective and efficient delivery of electrical energy to the myocardium via the lead is dependent on many factors to be discussed in this review. However, despite numerous evolutionary changes occurring in the cathode's material, design, and surface configuration, it was not until the incorporation of steroid‐elution to the electrode‐tissue interface that reliable and significantly low stimulation threshold cardiac pacing became possible. |
| doi_str_mv | 10.1111/pace.12461 |
| format | Article |
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The electrical stimulus that is delivered to this interface is responsible for myocyte depolarization with consequent cardiac contraction. The process by which this occurs is reasonably well understood and any explanation requires a basic understanding of the physics and cellular electrophysiology of pacing. The effective and efficient delivery of electrical energy to the myocardium via the lead is dependent on many factors to be discussed in this review. 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The electrical stimulus that is delivered to this interface is responsible for myocyte depolarization with consequent cardiac contraction. The process by which this occurs is reasonably well understood and any explanation requires a basic understanding of the physics and cellular electrophysiology of pacing. The effective and efficient delivery of electrical energy to the myocardium via the lead is dependent on many factors to be discussed in this review. 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| identifier | ISSN: 0147-8389 |
| ispartof | Pacing and clinical electrophysiology, 2014-09, Vol.37 (9), p.1232-1249 |
| issn | 0147-8389 1540-8159 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adrenal Cortex Hormones - administration & dosage biomedical engineering Defibrillators, Implantable Electric Power Supplies Electrodes, Implanted Endocardium - cytology Equipment Design Humans Myocardium - cytology Pacemaker, Artificial pacing Surface Properties |
| title | The Electrode-Tissue Interface: The Revolutionary Role of Steroid-Elution |
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