Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties

OPN (osteopontin) is a multiphosphorylated extracellular glycoprotein, which has important roles in bone remodelling, inflammation and cancer metastasis. OPN regulates cell spreading and adhesion primarily through its association with several integrins such as αvβ3, and its phosphorylation affects t...

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Veröffentlicht in:	Biochemical journal 2014-10, Vol.463 (1), p.93-102
Hauptverfasser:	Kariya, Yoshinobu, Kanno, Mayumi, Matsumoto-Morita, Kana, Konno, Midori, Yamaguchi, Yoshiki, Hashimoto, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion - physiology Cell Line, Tumor Glycosylation HEK293 Cells Humans Integrin alphaVbeta3 - genetics Integrin alphaVbeta3 - metabolism Osteopontin - genetics Osteopontin - metabolism Phosphorylation - physiology
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