Establishing the Timing of Implantation in the Harlan Porcellus Dutch and New Zealand White Rabbit and the Han Wistar Rat
The purpose of this study was to establish the timing of the onset of implantation in both the Harlan Porcellus Dutch and New Zealand White rabbit and the Han Wistar rat. Implantation was initiated on Day 5 (rat) and 7 (rabbit) and established by Day 7 and 8 of gestation in the rat and rabbit, respe...
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| Veröffentlicht in: | Regulatory toxicology and pharmacology 1996-02, Vol.23 (1), p.69-73 |
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| container_end_page | 73 |
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| container_title | Regulatory toxicology and pharmacology |
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| creator | Garside, Debbie A. Charlton, Allen Heath, Kate J. |
| description | The purpose of this study was to establish the timing of the onset of implantation in both the Harlan Porcellus Dutch and New Zealand White rabbit and the Han Wistar rat. Implantation was initiated on Day 5 (rat) and 7 (rabbit) and established by Day 7 and 8 of gestation in the rat and rabbit, respectively. Recent guidelines on toxicity testing during embryo–fetal development studies require that maternal exposure to pharmaceutical compounds does not occur until after implantation has taken place. In order to ensure that this is the case, female Harlan Porcellus Dutch and New Zealand White rabbits and Han Wistar rats were sacrificed on different days of gestation, over the expected periods of implantation. The presence of preimplantation blastocysts in the uterus was investigated, and evidence of established implantation sites was assessed. |
| doi_str_mv | 10.1006/rtph.1996.0010 |
| format | Article |
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Implantation was initiated on Day 5 (rat) and 7 (rabbit) and established by Day 7 and 8 of gestation in the rat and rabbit, respectively. Recent guidelines on toxicity testing during embryo–fetal development studies require that maternal exposure to pharmaceutical compounds does not occur until after implantation has taken place. In order to ensure that this is the case, female Harlan Porcellus Dutch and New Zealand White rabbits and Han Wistar rats were sacrificed on different days of gestation, over the expected periods of implantation. The presence of preimplantation blastocysts in the uterus was investigated, and evidence of established implantation sites was assessed.</description><identifier>ISSN: 0273-2300</identifier><identifier>EISSN: 1096-0295</identifier><identifier>DOI: 10.1006/rtph.1996.0010</identifier><identifier>PMID: 8628922</identifier><identifier>CODEN: RTOPDW</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Azo Compounds ; Biological and medical sciences ; Blastocyst - ultrastructure ; Coloring Agents ; Drug toxicity and drugs side effects treatment ; Embryo Implantation ; Embryo Implantation, Delayed - physiology ; Embryo Transfer ; Female ; Gestational Age ; Medical sciences ; Pharmacology. Drug treatments ; Rabbits ; Random Allocation ; Rats ; Rats, Wistar ; Species Specificity ; Time Factors ; Toxicity: osteoarticular system ; Trypan Blue ; Uterus - ultrastructure</subject><ispartof>Regulatory toxicology and pharmacology, 1996-02, Vol.23 (1), p.69-73</ispartof><rights>1996 Academic Press</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-d266f265bb82a9519080800041dc2da6598d4b3c1936f41e10c4c68a8cdf9c4f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0273230096900100$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3057324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8628922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garside, Debbie A.</creatorcontrib><creatorcontrib>Charlton, Allen</creatorcontrib><creatorcontrib>Heath, Kate J.</creatorcontrib><title>Establishing the Timing of Implantation in the Harlan Porcellus Dutch and New Zealand White Rabbit and the Han Wistar Rat</title><title>Regulatory toxicology and pharmacology</title><addtitle>Regul Toxicol Pharmacol</addtitle><description>The purpose of this study was to establish the timing of the onset of implantation in both the Harlan Porcellus Dutch and New Zealand White rabbit and the Han Wistar rat. Implantation was initiated on Day 5 (rat) and 7 (rabbit) and established by Day 7 and 8 of gestation in the rat and rabbit, respectively. Recent guidelines on toxicity testing during embryo–fetal development studies require that maternal exposure to pharmaceutical compounds does not occur until after implantation has taken place. In order to ensure that this is the case, female Harlan Porcellus Dutch and New Zealand White rabbits and Han Wistar rats were sacrificed on different days of gestation, over the expected periods of implantation. The presence of preimplantation blastocysts in the uterus was investigated, and evidence of established implantation sites was assessed.</description><subject>Animals</subject><subject>Azo Compounds</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - ultrastructure</subject><subject>Coloring Agents</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Embryo Implantation</subject><subject>Embryo Implantation, Delayed - physiology</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Species Specificity</subject><subject>Time Factors</subject><subject>Toxicity: osteoarticular system</subject><subject>Trypan Blue</subject><subject>Uterus - ultrastructure</subject><issn>0273-2300</issn><issn>1096-0295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFPHCEUh0mjsav12lsTDqa3WR_MDAtHo7ZusqnG2Jh4IQwwHZoZZgWmxv--jLvxZjjwwu97j5cPoa8ElgSAnYe07ZZECLYEIPAJLQgIVgAV9QFaAF2VBS0BPqPjGP8CAOV8dYSOOKNcULpAr9cxqaZ3sXP-D06dxQ9umMuxxeth2yufVHKjx86_pTcq5Dd8NwZt-36K-GpKusPKG_zLvuAnq_q5fuxcsvheNY1Lb-Gu1-NHl_8LOUlf0GGr-mhP9_cJ-v3j-uHyptjc_lxfXmwKXbE6FYYy1lJWNw2nStREAM8HoCJGU6NYLbipmlITUbK2IpaArjTjimvTCl215Qn6vpu7DePzZGOSg4vz8srbcYqS1Aw4EyKDyx2owxhjsK3cBjeo8CoJyNm1nF3L2bWcXeeGb_vJUzNY847v5eb8bJ-rqFXfBuW1i-9YCfWqpFXG-A6z2cI_Z4OM2lmvrXHB6iTN6D7a4D9yoJo4</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Garside, Debbie A.</creator><creator>Charlton, Allen</creator><creator>Heath, Kate J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960201</creationdate><title>Establishing the Timing of Implantation in the Harlan Porcellus Dutch and New Zealand White Rabbit and the Han Wistar Rat</title><author>Garside, Debbie A. ; Charlton, Allen ; Heath, Kate J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-d266f265bb82a9519080800041dc2da6598d4b3c1936f41e10c4c68a8cdf9c4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Azo Compounds</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - ultrastructure</topic><topic>Coloring Agents</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Embryo Implantation</topic><topic>Embryo Implantation, Delayed - physiology</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Species Specificity</topic><topic>Time Factors</topic><topic>Toxicity: osteoarticular system</topic><topic>Trypan Blue</topic><topic>Uterus - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garside, Debbie A.</creatorcontrib><creatorcontrib>Charlton, Allen</creatorcontrib><creatorcontrib>Heath, Kate J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Regulatory toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garside, Debbie A.</au><au>Charlton, Allen</au><au>Heath, Kate J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishing the Timing of Implantation in the Harlan Porcellus Dutch and New Zealand White Rabbit and the Han Wistar Rat</atitle><jtitle>Regulatory toxicology and pharmacology</jtitle><addtitle>Regul Toxicol Pharmacol</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>23</volume><issue>1</issue><spage>69</spage><epage>73</epage><pages>69-73</pages><issn>0273-2300</issn><eissn>1096-0295</eissn><coden>RTOPDW</coden><abstract>The purpose of this study was to establish the timing of the onset of implantation in both the Harlan Porcellus Dutch and New Zealand White rabbit and the Han Wistar rat. Implantation was initiated on Day 5 (rat) and 7 (rabbit) and established by Day 7 and 8 of gestation in the rat and rabbit, respectively. Recent guidelines on toxicity testing during embryo–fetal development studies require that maternal exposure to pharmaceutical compounds does not occur until after implantation has taken place. In order to ensure that this is the case, female Harlan Porcellus Dutch and New Zealand White rabbits and Han Wistar rats were sacrificed on different days of gestation, over the expected periods of implantation. The presence of preimplantation blastocysts in the uterus was investigated, and evidence of established implantation sites was assessed.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8628922</pmid><doi>10.1006/rtph.1996.0010</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0273-2300 |
| ispartof | Regulatory toxicology and pharmacology, 1996-02, Vol.23 (1), p.69-73 |
| issn | 0273-2300 1096-0295 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15608699 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Azo Compounds Biological and medical sciences Blastocyst - ultrastructure Coloring Agents Drug toxicity and drugs side effects treatment Embryo Implantation Embryo Implantation, Delayed - physiology Embryo Transfer Female Gestational Age Medical sciences Pharmacology. Drug treatments Rabbits Random Allocation Rats Rats, Wistar Species Specificity Time Factors Toxicity: osteoarticular system Trypan Blue Uterus - ultrastructure |
| title | Establishing the Timing of Implantation in the Harlan Porcellus Dutch and New Zealand White Rabbit and the Han Wistar Rat |
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