Determination of lead, zinc, potassium, calcium, copper and sodium in human cataract lenses
Concentrations of Pb, Zn, K, Ca, Cu and Na were determined in several human cataract and clear lenses, obtained from patients from two contrasting environmental regions in India, and the values were compared. When compared with the results obtained for samples of clear lenses, the mean concentration...
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| Veröffentlicht in: | The Science of the total environment 1996-03, Vol.181 (2), p.161-165 |
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| container_title | The Science of the total environment |
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| creator | SHUKLA, N MOITRA, J. K TRIVEDI, R. C |
| description | Concentrations of Pb, Zn, K, Ca, Cu and Na were determined in several human cataract and clear lenses, obtained from patients from two contrasting environmental regions in India, and the values were compared. When compared with the results obtained for samples of clear lenses, the mean concentration values of cataract lenses showed significant changes on the basis of the Mann-Whitney test. In cataract lenses, Pb and Zn showed an inverse correlation of r = -0.83; y = -1.64x + 457. Ca and K also showed an inverse correlation of r = -0.71; y = -0.34x + 3.6. No significant correlations were found between any other elements. The distribution of Pb, Zn, Ca and K were studied and their importance in ocular tissues is discussed. The molecules present in the eye lens lattice have undergone some conformational alterations due to intrusion of Pb and Ca ions and extrusion of Zn and K ions through the process of ion-exchange, thereby influencing the transparency of the lens. |
| doi_str_mv | 10.1016/0048-9697(95)05006-X |
| format | Article |
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K</creatorcontrib><creatorcontrib>TRIVEDI, R. C</creatorcontrib><title>Determination of lead, zinc, potassium, calcium, copper and sodium in human cataract lenses</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Concentrations of Pb, Zn, K, Ca, Cu and Na were determined in several human cataract and clear lenses, obtained from patients from two contrasting environmental regions in India, and the values were compared. When compared with the results obtained for samples of clear lenses, the mean concentration values of cataract lenses showed significant changes on the basis of the Mann-Whitney test. In cataract lenses, Pb and Zn showed an inverse correlation of r = -0.83; y = -1.64x + 457. Ca and K also showed an inverse correlation of r = -0.71; y = -0.34x + 3.6. No significant correlations were found between any other elements. The distribution of Pb, Zn, Ca and K were studied and their importance in ocular tissues is discussed. The molecules present in the eye lens lattice have undergone some conformational alterations due to intrusion of Pb and Ca ions and extrusion of Zn and K ions through the process of ion-exchange, thereby influencing the transparency of the lens.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Cataract - metabolism</subject><subject>Copper - metabolism</subject><subject>Environmental Exposure</subject><subject>Environmental pollutants toxicology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Lead - metabolism</subject><subject>Medical sciences</subject><subject>Metals - metabolism</subject><subject>Middle Aged</subject><subject>Sodium - metabolism</subject><subject>Spectrophotometry, Atomic</subject><subject>Toxicology</subject><subject>Zinc - metabolism</subject><issn>0048-9697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhH0AlVL4ByD5gBBIDfhRO_YRladUiQtIlThYjrMRQYkT7OQAvx6XVt3LrmZm5_AhdEbJDSVU3hKyUJmWOr_S4poIQmS2PkDTvXyEjmP8ImlyRSdoohQjXIkp-riHAUJbezvUncddhRuw5Rz_1t7Ncd8NNsZ6bOfY2cZtj67vIWDrSxy7Mkm49vhzbK1PmcEG64bU4SPEE3RY2SbC6W7P0Pvjw9vyOVu9Pr0s71aZ45INmdCMMVpVmtMi57RkqhCCClcIKHWhweVMAigBqpSKE14QVpCclgCUaaIrPkOX294-dN8jxMG0dXTQNNZDN0ZDhSRK0kUKLrZBF7oYA1SmD3Vrw4-hxGw4mg0wswFmtDD_HM06vZ3v-seihXL_tIOY_Iudb2PCVAXrXR33MZ5KNVP8D6m0fHw</recordid><startdate>19960315</startdate><enddate>19960315</enddate><creator>SHUKLA, N</creator><creator>MOITRA, J. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of lead, zinc, potassium, calcium, copper and sodium in human cataract lenses</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>1996-03-15</date><risdate>1996</risdate><volume>181</volume><issue>2</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0048-9697</issn><coden>STENDL</coden><abstract>Concentrations of Pb, Zn, K, Ca, Cu and Na were determined in several human cataract and clear lenses, obtained from patients from two contrasting environmental regions in India, and the values were compared. When compared with the results obtained for samples of clear lenses, the mean concentration values of cataract lenses showed significant changes on the basis of the Mann-Whitney test. In cataract lenses, Pb and Zn showed an inverse correlation of r = -0.83; y = -1.64x + 457. Ca and K also showed an inverse correlation of r = -0.71; y = -0.34x + 3.6. No significant correlations were found between any other elements. The distribution of Pb, Zn, Ca and K were studied and their importance in ocular tissues is discussed. The molecules present in the eye lens lattice have undergone some conformational alterations due to intrusion of Pb and Ca ions and extrusion of Zn and K ions through the process of ion-exchange, thereby influencing the transparency of the lens.</abstract><cop>Shannon</cop><pub>Elsevier Science</pub><pmid>8820385</pmid><doi>10.1016/0048-9697(95)05006-X</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Biological and medical sciences Calcium - metabolism Cataract - metabolism Copper - metabolism Environmental Exposure Environmental pollutants toxicology General aspects Humans Lead - metabolism Medical sciences Metals - metabolism Middle Aged Sodium - metabolism Spectrophotometry, Atomic Toxicology Zinc - metabolism |
| title | Determination of lead, zinc, potassium, calcium, copper and sodium in human cataract lenses |
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