Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome
It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptors (apomorphine-induced Growth Hormone (GH) secretion), and the inhibitory efficacy of G-pro...
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Veröffentlicht in: | Journal of Neural Transmission 1995-01, Vol.102 (2), p.149-157 |
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creator | HEINZ, A LICHTENBERG-KRAAG, B BAUM, S. S GRÄF, K KRÜGER, F DETTLING, M ROMMELSPACHER, H |
description | It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptors (apomorphine-induced Growth Hormone (GH) secretion), and the inhibitory efficacy of G-proteins on adenylyl cyclase activity (as an indicator for dopamine D2-receptor coupled second messenger mechanisms) were measured in 45 alcohol-dependent patients before and after detoxification and in 10 healthy controls. The time needed to adjust to abstinence conditions differed between patients with good and poor treatment outcome. In subsequent abstainers, effects of alcohol withdrawal were already found during the first 24 hours of abstinence (normalisation of GH response, increases in dopamine levels and the inhibitory efficacy of G-proteins). During the next 7 days of abstinence, no more significant changes were observed in the assessed variables. In subsequent relapsers, no significant effect of acute ethanol withdrawal on the same measures was found. However, at day 8 of abstinence, increases in apomorphine-induced GH secretion (towards normalisation), in dopamine plasma levels, and in the inhibitory efficacy of G-proteins (towards above-normal levels) were observed. This retarded adjustment of dopaminergic signal transduction seems to reflect the relapse risk of treatment nonresponders. |
doi_str_mv | 10.1007/BF01276510 |
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S ; GRÄF, K ; KRÜGER, F ; DETTLING, M ; ROMMELSPACHER, H</creator><creatorcontrib>HEINZ, A ; LICHTENBERG-KRAAG, B ; BAUM, S. S ; GRÄF, K ; KRÜGER, F ; DETTLING, M ; ROMMELSPACHER, H</creatorcontrib><description>It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptors (apomorphine-induced Growth Hormone (GH) secretion), and the inhibitory efficacy of G-proteins on adenylyl cyclase activity (as an indicator for dopamine D2-receptor coupled second messenger mechanisms) were measured in 45 alcohol-dependent patients before and after detoxification and in 10 healthy controls. The time needed to adjust to abstinence conditions differed between patients with good and poor treatment outcome. In subsequent abstainers, effects of alcohol withdrawal were already found during the first 24 hours of abstinence (normalisation of GH response, increases in dopamine levels and the inhibitory efficacy of G-proteins). During the next 7 days of abstinence, no more significant changes were observed in the assessed variables. In subsequent relapsers, no significant effect of acute ethanol withdrawal on the same measures was found. However, at day 8 of abstinence, increases in apomorphine-induced GH secretion (towards normalisation), in dopamine plasma levels, and in the inhibitory efficacy of G-proteins (towards above-normal levels) were observed. This retarded adjustment of dopaminergic signal transduction seems to reflect the relapse risk of treatment nonresponders.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF01276510</identifier><identifier>PMID: 8748679</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Adult ; Alcoholism - drug therapy ; Alcoholism - metabolism ; Alcoholism - physiopathology ; Alcoholism and acute alcohol poisoning ; Apomorphine - pharmacology ; Biological and medical sciences ; Dopamine - metabolism ; Growth Hormone - metabolism ; GTP-Binding Proteins - drug effects ; GTP-Binding Proteins - metabolism ; Humans ; Medical sciences ; Middle Aged ; Time Factors ; Toxicology ; Treatment Outcome</subject><ispartof>Journal of Neural Transmission, 1995-01, Vol.102 (2), p.149-157</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-411e8e9b47e262089c379e25ca4baccf3c02083672f87f3e35e834edd33061153</citedby><cites>FETCH-LOGICAL-c311t-411e8e9b47e262089c379e25ca4baccf3c02083672f87f3e35e834edd33061153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2920763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8748679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HEINZ, A</creatorcontrib><creatorcontrib>LICHTENBERG-KRAAG, B</creatorcontrib><creatorcontrib>BAUM, S. S</creatorcontrib><creatorcontrib>GRÄF, K</creatorcontrib><creatorcontrib>KRÜGER, F</creatorcontrib><creatorcontrib>DETTLING, M</creatorcontrib><creatorcontrib>ROMMELSPACHER, H</creatorcontrib><title>Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm Gen Sect</addtitle><description>It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptors (apomorphine-induced Growth Hormone (GH) secretion), and the inhibitory efficacy of G-proteins on adenylyl cyclase activity (as an indicator for dopamine D2-receptor coupled second messenger mechanisms) were measured in 45 alcohol-dependent patients before and after detoxification and in 10 healthy controls. The time needed to adjust to abstinence conditions differed between patients with good and poor treatment outcome. In subsequent abstainers, effects of alcohol withdrawal were already found during the first 24 hours of abstinence (normalisation of GH response, increases in dopamine levels and the inhibitory efficacy of G-proteins). During the next 7 days of abstinence, no more significant changes were observed in the assessed variables. In subsequent relapsers, no significant effect of acute ethanol withdrawal on the same measures was found. However, at day 8 of abstinence, increases in apomorphine-induced GH secretion (towards normalisation), in dopamine plasma levels, and in the inhibitory efficacy of G-proteins (towards above-normal levels) were observed. This retarded adjustment of dopaminergic signal transduction seems to reflect the relapse risk of treatment nonresponders.</description><subject>Adult</subject><subject>Alcoholism - drug therapy</subject><subject>Alcoholism - metabolism</subject><subject>Alcoholism - physiopathology</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Apomorphine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dopamine - metabolism</subject><subject>Growth Hormone - metabolism</subject><subject>GTP-Binding Proteins - drug effects</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Treatment Outcome</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLxTAQRoMoen1s3AtZiAuhOmnapF2q-ALBja5L7nSikba5Jrk-8M8b8aKrgW8OHzOHsX0BJwJAn55fgSi1qgWssZmoZF2ISsl1NgMJULS1qrbYdowvACCEbjbZZqOrRul2xr4u31xPExK3PvBF8IOfnqjngdC_Ufjk3vLeL8zoJgpPDnkKZoqji9H5iRubKPCekv9w1qFJP6HL-YD-2Q8OI3936ZkvfC5PgUwaaUrcLxP6kXbZhjVDpL3V3GGPV5cPFzfF3f317cXZXYFSiFRUQlBD7bzSVKoSmhalbqms0VRzg2glQk6l0qVttJUka2pkRX0vJSgharnDjn5783uvS4qpy_cjDYOZyC9jJ2oFSskmg8e_IAYfYyDbLYIbTfjsBHQ_prt_0xk-WLUu5yP1f-hKbd4frvYmohls9oYu_mFlW4JWUn4DEiuHiQ</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>HEINZ, A</creator><creator>LICHTENBERG-KRAAG, B</creator><creator>BAUM, S. S</creator><creator>GRÄF, K</creator><creator>KRÜGER, F</creator><creator>DETTLING, M</creator><creator>ROMMELSPACHER, H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19950101</creationdate><title>Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome</title><author>HEINZ, A ; LICHTENBERG-KRAAG, B ; BAUM, S. S ; GRÄF, K ; KRÜGER, F ; DETTLING, M ; ROMMELSPACHER, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-411e8e9b47e262089c379e25ca4baccf3c02083672f87f3e35e834edd33061153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Alcoholism - drug therapy</topic><topic>Alcoholism - metabolism</topic><topic>Alcoholism - physiopathology</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Apomorphine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dopamine - metabolism</topic><topic>Growth Hormone - metabolism</topic><topic>GTP-Binding Proteins - drug effects</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Time Factors</topic><topic>Toxicology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEINZ, A</creatorcontrib><creatorcontrib>LICHTENBERG-KRAAG, B</creatorcontrib><creatorcontrib>BAUM, S. S</creatorcontrib><creatorcontrib>GRÄF, K</creatorcontrib><creatorcontrib>KRÜGER, F</creatorcontrib><creatorcontrib>DETTLING, M</creatorcontrib><creatorcontrib>ROMMELSPACHER, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEINZ, A</au><au>LICHTENBERG-KRAAG, B</au><au>BAUM, S. S</au><au>GRÄF, K</au><au>KRÜGER, F</au><au>DETTLING, M</au><au>ROMMELSPACHER, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm Gen Sect</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>102</volume><issue>2</issue><spage>149</spage><epage>157</epage><pages>149-157</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptors (apomorphine-induced Growth Hormone (GH) secretion), and the inhibitory efficacy of G-proteins on adenylyl cyclase activity (as an indicator for dopamine D2-receptor coupled second messenger mechanisms) were measured in 45 alcohol-dependent patients before and after detoxification and in 10 healthy controls. The time needed to adjust to abstinence conditions differed between patients with good and poor treatment outcome. In subsequent abstainers, effects of alcohol withdrawal were already found during the first 24 hours of abstinence (normalisation of GH response, increases in dopamine levels and the inhibitory efficacy of G-proteins). During the next 7 days of abstinence, no more significant changes were observed in the assessed variables. In subsequent relapsers, no significant effect of acute ethanol withdrawal on the same measures was found. However, at day 8 of abstinence, increases in apomorphine-induced GH secretion (towards normalisation), in dopamine plasma levels, and in the inhibitory efficacy of G-proteins (towards above-normal levels) were observed. This retarded adjustment of dopaminergic signal transduction seems to reflect the relapse risk of treatment nonresponders.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>8748679</pmid><doi>10.1007/BF01276510</doi><tpages>9</tpages></addata></record> |
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subjects | Adult Alcoholism - drug therapy Alcoholism - metabolism Alcoholism - physiopathology Alcoholism and acute alcohol poisoning Apomorphine - pharmacology Biological and medical sciences Dopamine - metabolism Growth Hormone - metabolism GTP-Binding Proteins - drug effects GTP-Binding Proteins - metabolism Humans Medical sciences Middle Aged Time Factors Toxicology Treatment Outcome |
title | Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome |
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