Early trophoblast invasion and placentation in women with different PCOS phenotypes
Abstract This study evaluated the impact of different phenotypes of polycystic ovary syndrome (PCOS) on early trophoblast invasion and placentation. Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis...
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| Veröffentlicht in: | Reproductive biomedicine online 2014-09, Vol.29 (3), p.370-381 |
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| creator | Palomba, Stefano Falbo, Angela Chiossi, Giuseppe Tolino, Achille Tucci, Luigi La Sala, Giovanni Battista Zullo, Fulvio |
| description | Abstract This study evaluated the impact of different phenotypes of polycystic ovary syndrome (PCOS) on early trophoblast invasion and placentation. Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis of trophoblastic and decidual tissue and macroscopic and microscopic assessment of the placentas were performed. Implantation-site vessels with endovascular trophoblast differed significantly among PCOS phenotypes. Placental weight, thickness, density and fetal–placental weight ratio were significantly different in the full-blown and non-polycystic ovary (PCO) phenotypes versus the ovulatory and non-hyperandrogenic phenotypes. The incidence of macroscopic placental lesions was only significantly different between controls and the full-blown and non-PCO phenotypes. The overall incidence of microscopic placental lesions was significantly different among PCOS phenotypes and was significantly higher in the full-blown and non-PCO phenotypes than in the ovulatory and non-hyperandrogenic phenotypes. The rates of chorionic villitis and intervillositis were significantly higher in full-blown and non-PCO phenotypes than in ovulatory and non-hyperandrogenic phenotypes. In conclusion, alterations in early trophoblast invasion and placentation observed in PCOS vary widely according to phenotype. |
| doi_str_mv | 10.1016/j.rbmo.2014.04.010 |
| format | Article |
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Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis of trophoblastic and decidual tissue and macroscopic and microscopic assessment of the placentas were performed. Implantation-site vessels with endovascular trophoblast differed significantly among PCOS phenotypes. Placental weight, thickness, density and fetal–placental weight ratio were significantly different in the full-blown and non-polycystic ovary (PCO) phenotypes versus the ovulatory and non-hyperandrogenic phenotypes. The incidence of macroscopic placental lesions was only significantly different between controls and the full-blown and non-PCO phenotypes. The overall incidence of microscopic placental lesions was significantly different among PCOS phenotypes and was significantly higher in the full-blown and non-PCO phenotypes than in the ovulatory and non-hyperandrogenic phenotypes. The rates of chorionic villitis and intervillositis were significantly higher in full-blown and non-PCO phenotypes than in ovulatory and non-hyperandrogenic phenotypes. In conclusion, alterations in early trophoblast invasion and placentation observed in PCOS vary widely according to phenotype.</description><identifier>ISSN: 1472-6483</identifier><identifier>EISSN: 1472-6491</identifier><identifier>DOI: 10.1016/j.rbmo.2014.04.010</identifier><identifier>PMID: 24928355</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Female ; Humans ; insulin resistance ; Obstetrics and Gynecology ; PCOS ; Phenotype ; phenotypes ; Placenta - pathology ; Placenta - physiopathology ; placentation ; Placentation - physiology ; Polycystic Ovary Syndrome - pathology ; Polycystic Ovary Syndrome - physiopathology ; Pregnancy ; trophoblast invasion ; Trophoblasts - pathology ; Trophoblasts - physiology</subject><ispartof>Reproductive biomedicine online, 2014-09, Vol.29 (3), p.370-381</ispartof><rights>Reproductive Healthcare Ltd.</rights><rights>2014 Reproductive Healthcare Ltd.</rights><rights>Copyright © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-73f528ee0ae927e42c99cdef200b737ba459bae698815e75e9d81900bbc44df43</citedby><cites>FETCH-LOGICAL-c481t-73f528ee0ae927e42c99cdef200b737ba459bae698815e75e9d81900bbc44df43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rbmo.2014.04.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24928355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palomba, Stefano</creatorcontrib><creatorcontrib>Falbo, Angela</creatorcontrib><creatorcontrib>Chiossi, Giuseppe</creatorcontrib><creatorcontrib>Tolino, Achille</creatorcontrib><creatorcontrib>Tucci, Luigi</creatorcontrib><creatorcontrib>La Sala, Giovanni Battista</creatorcontrib><creatorcontrib>Zullo, Fulvio</creatorcontrib><title>Early trophoblast invasion and placentation in women with different PCOS phenotypes</title><title>Reproductive biomedicine online</title><addtitle>Reprod Biomed Online</addtitle><description>Abstract This study evaluated the impact of different phenotypes of polycystic ovary syndrome (PCOS) on early trophoblast invasion and placentation. Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis of trophoblastic and decidual tissue and macroscopic and microscopic assessment of the placentas were performed. Implantation-site vessels with endovascular trophoblast differed significantly among PCOS phenotypes. Placental weight, thickness, density and fetal–placental weight ratio were significantly different in the full-blown and non-polycystic ovary (PCO) phenotypes versus the ovulatory and non-hyperandrogenic phenotypes. The incidence of macroscopic placental lesions was only significantly different between controls and the full-blown and non-PCO phenotypes. The overall incidence of microscopic placental lesions was significantly different among PCOS phenotypes and was significantly higher in the full-blown and non-PCO phenotypes than in the ovulatory and non-hyperandrogenic phenotypes. The rates of chorionic villitis and intervillositis were significantly higher in full-blown and non-PCO phenotypes than in ovulatory and non-hyperandrogenic phenotypes. In conclusion, alterations in early trophoblast invasion and placentation observed in PCOS vary widely according to phenotype.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>insulin resistance</subject><subject>Obstetrics and Gynecology</subject><subject>PCOS</subject><subject>Phenotype</subject><subject>phenotypes</subject><subject>Placenta - pathology</subject><subject>Placenta - physiopathology</subject><subject>placentation</subject><subject>Placentation - physiology</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Pregnancy</subject><subject>trophoblast invasion</subject><subject>Trophoblasts - pathology</subject><subject>Trophoblasts - physiology</subject><issn>1472-6483</issn><issn>1472-6491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFr3DAQhUVpadKkf6CH4mMvuxnJ0lqCUChL2gQCKWxyFrI8ZrW1JVfSpuy_j8wmOfQQGKRB894DfUPIFwpLCnR1sVvGdgxLBpQvoRSFd-SU8oYtVlzR96-9rE_Ip5R2AFSCrD-SE8YVk7UQp2RzZeJwqHIM0za0g0m5cv7RJBd8ZXxXTYOx6LPJ84Pz1b8wYjld3lad63uMZVj9Xt9tqmmLPuTDhOmcfOjNkPDz831GHn5e3a-vF7d3v27WP24XlkuaF03dCyYRwaBiDXJmlbId9gygbeqmNVyo1uBKSUkFNgJVJ6kqw9Zy3vW8PiPfjrlTDH_3mLIeXbI4DMZj2CdNxQqE5JKLImVHqY0hpYi9nqIbTTxoCnqGqXd6hqlnmBpKUSimr8_5-3bE7tXyQq8ILo8CLL98dBh1sg69xc5FtFl3wb2d__0_ux2cd9YMf_CAaRf20Rd-murENOjNvM55m5QDMM5Z_QRC7ps0</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Palomba, Stefano</creator><creator>Falbo, Angela</creator><creator>Chiossi, Giuseppe</creator><creator>Tolino, Achille</creator><creator>Tucci, Luigi</creator><creator>La Sala, Giovanni Battista</creator><creator>Zullo, Fulvio</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Early trophoblast invasion and placentation in women with different PCOS phenotypes</title><author>Palomba, Stefano ; Falbo, Angela ; Chiossi, Giuseppe ; Tolino, Achille ; Tucci, Luigi ; La Sala, Giovanni Battista ; Zullo, Fulvio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-73f528ee0ae927e42c99cdef200b737ba459bae698815e75e9d81900bbc44df43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>insulin resistance</topic><topic>Obstetrics and Gynecology</topic><topic>PCOS</topic><topic>Phenotype</topic><topic>phenotypes</topic><topic>Placenta - pathology</topic><topic>Placenta - physiopathology</topic><topic>placentation</topic><topic>Placentation - physiology</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Pregnancy</topic><topic>trophoblast invasion</topic><topic>Trophoblasts - pathology</topic><topic>Trophoblasts - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palomba, Stefano</creatorcontrib><creatorcontrib>Falbo, Angela</creatorcontrib><creatorcontrib>Chiossi, Giuseppe</creatorcontrib><creatorcontrib>Tolino, Achille</creatorcontrib><creatorcontrib>Tucci, Luigi</creatorcontrib><creatorcontrib>La Sala, Giovanni Battista</creatorcontrib><creatorcontrib>Zullo, Fulvio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive biomedicine online</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palomba, Stefano</au><au>Falbo, Angela</au><au>Chiossi, Giuseppe</au><au>Tolino, Achille</au><au>Tucci, Luigi</au><au>La Sala, Giovanni Battista</au><au>Zullo, Fulvio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early trophoblast invasion and placentation in women with different PCOS phenotypes</atitle><jtitle>Reproductive biomedicine online</jtitle><addtitle>Reprod Biomed Online</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>29</volume><issue>3</issue><spage>370</spage><epage>381</epage><pages>370-381</pages><issn>1472-6483</issn><eissn>1472-6491</eissn><abstract>Abstract This study evaluated the impact of different phenotypes of polycystic ovary syndrome (PCOS) on early trophoblast invasion and placentation. Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis of trophoblastic and decidual tissue and macroscopic and microscopic assessment of the placentas were performed. Implantation-site vessels with endovascular trophoblast differed significantly among PCOS phenotypes. Placental weight, thickness, density and fetal–placental weight ratio were significantly different in the full-blown and non-polycystic ovary (PCO) phenotypes versus the ovulatory and non-hyperandrogenic phenotypes. The incidence of macroscopic placental lesions was only significantly different between controls and the full-blown and non-PCO phenotypes. The overall incidence of microscopic placental lesions was significantly different among PCOS phenotypes and was significantly higher in the full-blown and non-PCO phenotypes than in the ovulatory and non-hyperandrogenic phenotypes. The rates of chorionic villitis and intervillositis were significantly higher in full-blown and non-PCO phenotypes than in ovulatory and non-hyperandrogenic phenotypes. In conclusion, alterations in early trophoblast invasion and placentation observed in PCOS vary widely according to phenotype.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24928355</pmid><doi>10.1016/j.rbmo.2014.04.010</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Female Humans insulin resistance Obstetrics and Gynecology PCOS Phenotype phenotypes Placenta - pathology Placenta - physiopathology placentation Placentation - physiology Polycystic Ovary Syndrome - pathology Polycystic Ovary Syndrome - physiopathology Pregnancy trophoblast invasion Trophoblasts - pathology Trophoblasts - physiology |
| title | Early trophoblast invasion and placentation in women with different PCOS phenotypes |
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