Identification of a new immunogenic candidate conferring protection against Brucella melitensis infection in Mice

•Heat shock protein A from Brucella melitensis elicits mixed TH1/TH2 immune responses and.•Induces a strong recall proliferative response with.•High amounts of IFN-γ, IL-12, IL-10 and IL-6 and very low levels of IL-5 and IL-4 production.•This antigen also reduces bacterial load and significantly pro...

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Veröffentlicht in:	Molecular immunology 2014-11, Vol.62 (1), p.142-149
Hauptverfasser:	Ghasemi, Amir, Zarnani, Amir-Hassan, Ghoodjani, Abolfazl, Rezania, Simin, Salari, Mohammad Hossein, Jeddi-Tehrani, Mahmood
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - immunology Bacterial Proteins - isolation & purification Brucella melitensis Brucella melitensis - immunology Brucella Vaccine - immunology Brucella Vaccine - therapeutic use Brucellosis - prevention & control Cell Proliferation Female Heat shock protein Heat-Shock Proteins - immunology Heat-Shock Proteins - isolation & purification Immunization - methods Lymphocytes - physiology Mice Mice, Inbred BALB C Recombinant protein Recombinant Proteins - immunology Recombinant Proteins - isolation & purification Vaccine
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