Expression of secreted frizzled related protein 1, β-catenin and E-cadherin in colorectal carcinoma and its clinicopathological significances

To investigate the expression of secreted frizzled-related protein 1 (SFRP1), β-catenin and E-cadherin in colorectal carcinoma and its clinicopathological significance. The expression of SFRP1, β-catenin and E-cadherin mRNA and protein in tumor and pericancerous tissue samples from 60 cases of color...

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Veröffentlicht in:	Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2014-07, Vol.43 (4), p.397-405
Hauptverfasser:	Ou, Yu-rong, Liu, Juan, Gao, Shan, Jing, Gui-ying, Cheng, Ze-nong, Dong, Xiu-qin
Format:	Artikel
Sprache:	chi
Schlagworte:	Adult Aged Aged, 80 and over Antigens, CD beta Catenin - metabolism Cadherins - metabolism Colorectal Neoplasms - metabolism Female Humans Intercellular Signaling Peptides and Proteins - metabolism Lymphatic Metastasis Male Membrane Proteins - metabolism Middle Aged
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Zusammenfassung:	To investigate the expression of secreted frizzled-related protein 1 (SFRP1), β-catenin and E-cadherin in colorectal carcinoma and its clinicopathological significance. The expression of SFRP1, β-catenin and E-cadherin mRNA and protein in tumor and pericancerous tissue samples from 60 cases of colorectal cancer was assayed by reverse-transcription PCR and immunohistochemistry, respectively. The correlation of their expression with clinicopathological factors of colorectal cancer was analyzed. In 52/60 cases the relative mRNA expression of SFRP1 in cancer tissue and pericancerous tissue was 0.4837±0.1532 and 0.7170 ±0.1830; for β-catenin was 0.9293± 0.3705 and 0.6469±0.3166; and for E-cadherin was 0.5556±0.2535 and 0.9422±0.2372 (P
ISSN:	1008-9292