The Relationship of Body Mass and Fat Distribution With Incident Hypertension: Observations From the Dallas Heart Study
Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear. This study sought to determine the relationship between adipose tissue distribution and incident hypertension. Normotensive participants e...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 2014-09, Vol.64 (10), p.997-1002 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1002 |
|---|---|
| container_issue | 10 |
| container_start_page | 997 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 64 |
| creator | CHANDRA, Alvin NEELAND, Ian J BERRY, Jarett D AYERS, Colby R ROHATGI, Anand DAS, Sandeep R KHERA, Amit MCGUIRE, Darren K DE LEMOS, James A TURER, Aslan T |
| description | Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear.
This study sought to determine the relationship between adipose tissue distribution and incident hypertension.
Normotensive participants enrolled in the Dallas Heart Study were followed for a median of 7 years for the development of hypertension (systolic blood pressure [SBP] ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or initiation of blood pressure medications). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) was quantified by magnetic resonance imaging and proton-spectroscopic imaging, and lower body fat (LBF) was imaged by dual-energy x-ray absorptiometry. Multivariable relative risk regression was performed to test the association between individual fat depots and incident hypertension, adjusting for age, sex, race/ethnicity, diabetes, smoking, SBP, and body mass index (BMI).
Among 903 participants (median age, 40 years; 57% women; 60% nonwhite; median BMI 27.5 kg/m(2)), 230 (25%) developed incident hypertension. In multivariable analyses, higher BMI was significantly associated with incident hypertension (relative risk: 1.24; 95% confidence interval: 1.12 to 1.36, per 1-SD increase). However, when VAT, SAT, and LBF were added to the model, only VAT remained independently associated with incident hypertension (relative risk: 1.22; 95% confidence interval: 1.06 to 1.39, per 1-SD increase).
Increased visceral adiposity, but not total or subcutaneous adiposity, was robustly associated with incident hypertension. Additional studies will be needed to elucidate the mechanisms behind this association. |
| doi_str_mv | 10.1016/j.jacc.2014.05.057 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1560582434</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1560582434</sourcerecordid><originalsourceid>FETCH-LOGICAL-p241t-41eff8020fd32ee222fae7d6b0b1afd1c9de07e1c0f42054175ead40c0e752743</originalsourceid><addsrcrecordid>eNpF0N9LwzAQB_Agis4f_4APkhfBl9ZLmiytb-qcE5SBTnwsaXNhHV1bk1TZf29lE-HgHu7D3fEl5JxBzICNr1fxSpdlzIGJGORQao-MmJRplMhM7ZMRqERGDDJ1RI69XwHAOGXZITnikmXAEzEi34sl0lesdajaxi-rjraW3rVmQ1-091Q3hk51oJPKB1cV_a-iH1VY0qemrAw2gc42HbqAjR9GN3ReeHRf22106to1DcOBia5r7ekMtQv0LfRmc0oOrK49nu36CXmfPizuZ9Hz_PHp_vY56rhgIRIMrU2BgzUJR-ScW43KjAsomLaGlZlBUMhKsIKDFExJ1EZACagkVyI5IVfbvZ1rP3v0IV9XvsThnQbb3udMjkGmXCS_9GJH-2KNJu9ctdZuk_-FNYDLHdC-1LV1esjA_7tUqUwpmfwAWnh61g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1560582434</pqid></control><display><type>article</type><title>The Relationship of Body Mass and Fat Distribution With Incident Hypertension: Observations From the Dallas Heart Study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>CHANDRA, Alvin ; NEELAND, Ian J ; BERRY, Jarett D ; AYERS, Colby R ; ROHATGI, Anand ; DAS, Sandeep R ; KHERA, Amit ; MCGUIRE, Darren K ; DE LEMOS, James A ; TURER, Aslan T</creator><creatorcontrib>CHANDRA, Alvin ; NEELAND, Ian J ; BERRY, Jarett D ; AYERS, Colby R ; ROHATGI, Anand ; DAS, Sandeep R ; KHERA, Amit ; MCGUIRE, Darren K ; DE LEMOS, James A ; TURER, Aslan T</creatorcontrib><description>Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear.
This study sought to determine the relationship between adipose tissue distribution and incident hypertension.
Normotensive participants enrolled in the Dallas Heart Study were followed for a median of 7 years for the development of hypertension (systolic blood pressure [SBP] ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or initiation of blood pressure medications). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) was quantified by magnetic resonance imaging and proton-spectroscopic imaging, and lower body fat (LBF) was imaged by dual-energy x-ray absorptiometry. Multivariable relative risk regression was performed to test the association between individual fat depots and incident hypertension, adjusting for age, sex, race/ethnicity, diabetes, smoking, SBP, and body mass index (BMI).
Among 903 participants (median age, 40 years; 57% women; 60% nonwhite; median BMI 27.5 kg/m(2)), 230 (25%) developed incident hypertension. In multivariable analyses, higher BMI was significantly associated with incident hypertension (relative risk: 1.24; 95% confidence interval: 1.12 to 1.36, per 1-SD increase). However, when VAT, SAT, and LBF were added to the model, only VAT remained independently associated with incident hypertension (relative risk: 1.22; 95% confidence interval: 1.06 to 1.39, per 1-SD increase).
Increased visceral adiposity, but not total or subcutaneous adiposity, was robustly associated with incident hypertension. Additional studies will be needed to elucidate the mechanisms behind this association.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2014.05.057</identifier><identifier>PMID: 25190234</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Adult ; Age Distribution ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Fat Distribution - statistics & numerical data ; Body Mass Index ; Cardiology. Vascular system ; Cohort Studies ; Comorbidity ; Confidence Intervals ; Female ; Follow-Up Studies ; Heart ; Humans ; Hypertension - diagnosis ; Hypertension - epidemiology ; Incidence ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Obesity - diagnosis ; Obesity - epidemiology ; Regression Analysis ; Risk Assessment ; Sex Distribution ; Statistics, Nonparametric ; Texas</subject><ispartof>Journal of the American College of Cardiology, 2014-09, Vol.64 (10), p.997-1002</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28779775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25190234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHANDRA, Alvin</creatorcontrib><creatorcontrib>NEELAND, Ian J</creatorcontrib><creatorcontrib>BERRY, Jarett D</creatorcontrib><creatorcontrib>AYERS, Colby R</creatorcontrib><creatorcontrib>ROHATGI, Anand</creatorcontrib><creatorcontrib>DAS, Sandeep R</creatorcontrib><creatorcontrib>KHERA, Amit</creatorcontrib><creatorcontrib>MCGUIRE, Darren K</creatorcontrib><creatorcontrib>DE LEMOS, James A</creatorcontrib><creatorcontrib>TURER, Aslan T</creatorcontrib><title>The Relationship of Body Mass and Fat Distribution With Incident Hypertension: Observations From the Dallas Heart Study</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear.
This study sought to determine the relationship between adipose tissue distribution and incident hypertension.
Normotensive participants enrolled in the Dallas Heart Study were followed for a median of 7 years for the development of hypertension (systolic blood pressure [SBP] ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or initiation of blood pressure medications). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) was quantified by magnetic resonance imaging and proton-spectroscopic imaging, and lower body fat (LBF) was imaged by dual-energy x-ray absorptiometry. Multivariable relative risk regression was performed to test the association between individual fat depots and incident hypertension, adjusting for age, sex, race/ethnicity, diabetes, smoking, SBP, and body mass index (BMI).
Among 903 participants (median age, 40 years; 57% women; 60% nonwhite; median BMI 27.5 kg/m(2)), 230 (25%) developed incident hypertension. In multivariable analyses, higher BMI was significantly associated with incident hypertension (relative risk: 1.24; 95% confidence interval: 1.12 to 1.36, per 1-SD increase). However, when VAT, SAT, and LBF were added to the model, only VAT remained independently associated with incident hypertension (relative risk: 1.22; 95% confidence interval: 1.06 to 1.39, per 1-SD increase).
Increased visceral adiposity, but not total or subcutaneous adiposity, was robustly associated with incident hypertension. Additional studies will be needed to elucidate the mechanisms behind this association.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body Fat Distribution - statistics & numerical data</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Regression Analysis</subject><subject>Risk Assessment</subject><subject>Sex Distribution</subject><subject>Statistics, Nonparametric</subject><subject>Texas</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0N9LwzAQB_Agis4f_4APkhfBl9ZLmiytb-qcE5SBTnwsaXNhHV1bk1TZf29lE-HgHu7D3fEl5JxBzICNr1fxSpdlzIGJGORQao-MmJRplMhM7ZMRqERGDDJ1RI69XwHAOGXZITnikmXAEzEi34sl0lesdajaxi-rjraW3rVmQ1-091Q3hk51oJPKB1cV_a-iH1VY0qemrAw2gc42HbqAjR9GN3ReeHRf22106to1DcOBia5r7ekMtQv0LfRmc0oOrK49nu36CXmfPizuZ9Hz_PHp_vY56rhgIRIMrU2BgzUJR-ScW43KjAsomLaGlZlBUMhKsIKDFExJ1EZACagkVyI5IVfbvZ1rP3v0IV9XvsThnQbb3udMjkGmXCS_9GJH-2KNJu9ctdZuk_-FNYDLHdC-1LV1esjA_7tUqUwpmfwAWnh61g</recordid><startdate>20140909</startdate><enddate>20140909</enddate><creator>CHANDRA, Alvin</creator><creator>NEELAND, Ian J</creator><creator>BERRY, Jarett D</creator><creator>AYERS, Colby R</creator><creator>ROHATGI, Anand</creator><creator>DAS, Sandeep R</creator><creator>KHERA, Amit</creator><creator>MCGUIRE, Darren K</creator><creator>DE LEMOS, James A</creator><creator>TURER, Aslan T</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140909</creationdate><title>The Relationship of Body Mass and Fat Distribution With Incident Hypertension: Observations From the Dallas Heart Study</title><author>CHANDRA, Alvin ; NEELAND, Ian J ; BERRY, Jarett D ; AYERS, Colby R ; ROHATGI, Anand ; DAS, Sandeep R ; KHERA, Amit ; MCGUIRE, Darren K ; DE LEMOS, James A ; TURER, Aslan T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-41eff8020fd32ee222fae7d6b0b1afd1c9de07e1c0f42054175ead40c0e752743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body Fat Distribution - statistics & numerical data</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity - diagnosis</topic><topic>Obesity - epidemiology</topic><topic>Regression Analysis</topic><topic>Risk Assessment</topic><topic>Sex Distribution</topic><topic>Statistics, Nonparametric</topic><topic>Texas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHANDRA, Alvin</creatorcontrib><creatorcontrib>NEELAND, Ian J</creatorcontrib><creatorcontrib>BERRY, Jarett D</creatorcontrib><creatorcontrib>AYERS, Colby R</creatorcontrib><creatorcontrib>ROHATGI, Anand</creatorcontrib><creatorcontrib>DAS, Sandeep R</creatorcontrib><creatorcontrib>KHERA, Amit</creatorcontrib><creatorcontrib>MCGUIRE, Darren K</creatorcontrib><creatorcontrib>DE LEMOS, James A</creatorcontrib><creatorcontrib>TURER, Aslan T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHANDRA, Alvin</au><au>NEELAND, Ian J</au><au>BERRY, Jarett D</au><au>AYERS, Colby R</au><au>ROHATGI, Anand</au><au>DAS, Sandeep R</au><au>KHERA, Amit</au><au>MCGUIRE, Darren K</au><au>DE LEMOS, James A</au><au>TURER, Aslan T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship of Body Mass and Fat Distribution With Incident Hypertension: Observations From the Dallas Heart Study</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2014-09-09</date><risdate>2014</risdate><volume>64</volume><issue>10</issue><spage>997</spage><epage>1002</epage><pages>997-1002</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Obesity has been linked to the development of hypertension, but whether total adiposity or site-specific fat accumulation underpins this relationship is unclear.
This study sought to determine the relationship between adipose tissue distribution and incident hypertension.
Normotensive participants enrolled in the Dallas Heart Study were followed for a median of 7 years for the development of hypertension (systolic blood pressure [SBP] ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or initiation of blood pressure medications). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) was quantified by magnetic resonance imaging and proton-spectroscopic imaging, and lower body fat (LBF) was imaged by dual-energy x-ray absorptiometry. Multivariable relative risk regression was performed to test the association between individual fat depots and incident hypertension, adjusting for age, sex, race/ethnicity, diabetes, smoking, SBP, and body mass index (BMI).
Among 903 participants (median age, 40 years; 57% women; 60% nonwhite; median BMI 27.5 kg/m(2)), 230 (25%) developed incident hypertension. In multivariable analyses, higher BMI was significantly associated with incident hypertension (relative risk: 1.24; 95% confidence interval: 1.12 to 1.36, per 1-SD increase). However, when VAT, SAT, and LBF were added to the model, only VAT remained independently associated with incident hypertension (relative risk: 1.22; 95% confidence interval: 1.06 to 1.39, per 1-SD increase).
Increased visceral adiposity, but not total or subcutaneous adiposity, was robustly associated with incident hypertension. Additional studies will be needed to elucidate the mechanisms behind this association.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>25190234</pmid><doi>10.1016/j.jacc.2014.05.057</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2014-09, Vol.64 (10), p.997-1002 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1560582434 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Age Distribution Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Body Fat Distribution - statistics & numerical data Body Mass Index Cardiology. Vascular system Cohort Studies Comorbidity Confidence Intervals Female Follow-Up Studies Heart Humans Hypertension - diagnosis Hypertension - epidemiology Incidence Male Medical sciences Middle Aged Multivariate Analysis Obesity - diagnosis Obesity - epidemiology Regression Analysis Risk Assessment Sex Distribution Statistics, Nonparametric Texas |
| title | The Relationship of Body Mass and Fat Distribution With Incident Hypertension: Observations From the Dallas Heart Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T23%3A19%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Relationship%20of%20Body%20Mass%20and%20Fat%20Distribution%20With%20Incident%20Hypertension:%20Observations%20From%20the%20Dallas%20Heart%20Study&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=CHANDRA,%20Alvin&rft.date=2014-09-09&rft.volume=64&rft.issue=10&rft.spage=997&rft.epage=1002&rft.pages=997-1002&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/j.jacc.2014.05.057&rft_dat=%3Cproquest_pubme%3E1560582434%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1560582434&rft_id=info:pmid/25190234&rfr_iscdi=true |