Three-Component Coupling Reaction Triggered by Insertion of Arynes into the SO Bond of DMSO

Three-Component Coupling Reaction Triggered by Insertion of Arynes into the SO Bond of DMSO

An unprecedented three-component coupling reaction of arynes, α-bromo carbonyl compounds, and DMSO triggered by insertion of arynes into the SO bond of DMSO has been developed. The reaction can generate a wide range of multi­substituted aryl methyl thioethers in good yields, wherein DMSO serves as...

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Veröffentlicht in:Organic letters 2014-07, Vol.16 (14), p.3768-3771
Hauptverfasser: Liu, Feng-Lei, Chen, Jia-Rong, Zou, You-Quan, Wei, Qiang, Xiao, Wen-Jing
Format: Artikel
Sprache:eng
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Zusammenfassung:An unprecedented three-component coupling reaction of arynes, α-bromo carbonyl compounds, and DMSO triggered by insertion of arynes into the SO bond of DMSO has been developed. The reaction can generate a wide range of multi­substituted aryl methyl thioethers in good yields, wherein DMSO serves as both methyl­thiolation reagent and oxygen source.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501638x