Spiral Analysis in Subjects with Parkinson's Disease before and after Levodopa Treatment: A New Protocol with Stereophotogrammetric Systems
Purpose A method for the quantification of handwritten spirals in patients with Parkinson's disease (PD) pre and post levodopa treatment is reported. Methods Fifteen PD patients (mean age: 66.80±9.75 years) were assessed in the absence of medication (OFF condition) and under levodopa administra...
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| Veröffentlicht in: | Journal of applied biomaterials & functional materials 2014-01, Vol.12 (2), p.107-112 |
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| creator | Galli, Manuela Vimercati, Sara L. Manetti, Elena Cimolin, Veronica Albertini, Giorgio De Pandis, Maria F. |
| description | Purpose
A method for the quantification of handwritten spirals in patients with Parkinson's disease (PD) pre and post levodopa treatment is reported.
Methods
Fifteen PD patients (mean age: 66.80±9.75 years) were assessed in the absence of medication (OFF condition) and under levodopa administration (ON condition). The control group was composed of 15 age-matched healthy (H) individuals (mean age: 63.70±9.40). They were asked to hand draw a spiral at self-selected speed, without resting their forearm on the table. The participants drew on a paper sheet, using a normal pen. The trace of the pen was determined from the 3D coordinates of passive markers placed on the pen and on the sheet, acquired with an optoelectronic system and some parameters were identified and computed.
Results
The method revealed to be significant in highlighting the differences between H and PD subjects and in detecting pharmacologic effect. PD patients are impaired in spiral drawing execution and levodopa improves drawing performance, evidenced by spatio-temporal parameters and velocity profiles.
Conclusions
The protocol is easily employable in clinic analysis because of its simplicity, the short duration of the test, and the natural test conditions. These characteristics suggest the applicability of this protocol to other fields of motor and cognitive assessments. |
| doi_str_mv | 10.5301/jabfm.2012.9265 |
| format | Article |
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A method for the quantification of handwritten spirals in patients with Parkinson's disease (PD) pre and post levodopa treatment is reported.
Methods
Fifteen PD patients (mean age: 66.80±9.75 years) were assessed in the absence of medication (OFF condition) and under levodopa administration (ON condition). The control group was composed of 15 age-matched healthy (H) individuals (mean age: 63.70±9.40). They were asked to hand draw a spiral at self-selected speed, without resting their forearm on the table. The participants drew on a paper sheet, using a normal pen. The trace of the pen was determined from the 3D coordinates of passive markers placed on the pen and on the sheet, acquired with an optoelectronic system and some parameters were identified and computed.
Results
The method revealed to be significant in highlighting the differences between H and PD subjects and in detecting pharmacologic effect. PD patients are impaired in spiral drawing execution and levodopa improves drawing performance, evidenced by spatio-temporal parameters and velocity profiles.
Conclusions
The protocol is easily employable in clinic analysis because of its simplicity, the short duration of the test, and the natural test conditions. These characteristics suggest the applicability of this protocol to other fields of motor and cognitive assessments.</description><identifier>ISSN: 2280-8000</identifier><identifier>EISSN: 2280-8000</identifier><identifier>DOI: 10.5301/jabfm.2012.9265</identifier><identifier>PMID: 22798231</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Antiparkinson Agents - therapeutic use ; Female ; Humans ; Levodopa - therapeutic use ; Linear Models ; Male ; Middle Aged ; Parkinson Disease - drug therapy ; Parkinson Disease - physiopathology ; Photogrammetry ; Severity of Illness Index</subject><ispartof>Journal of applied biomaterials & functional materials, 2014-01, Vol.12 (2), p.107-112</ispartof><rights>2014 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-7fd37a2508df6196fb875f8d5ca9002a07645531575118b9069545cbb3fc424c3</citedby><cites>FETCH-LOGICAL-c561t-7fd37a2508df6196fb875f8d5ca9002a07645531575118b9069545cbb3fc424c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.5301/jabfm.2012.9265$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.5301/jabfm.2012.9265$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.5301/jabfm.2012.9265?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22798231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galli, Manuela</creatorcontrib><creatorcontrib>Vimercati, Sara L.</creatorcontrib><creatorcontrib>Manetti, Elena</creatorcontrib><creatorcontrib>Cimolin, Veronica</creatorcontrib><creatorcontrib>Albertini, Giorgio</creatorcontrib><creatorcontrib>De Pandis, Maria F.</creatorcontrib><title>Spiral Analysis in Subjects with Parkinson's Disease before and after Levodopa Treatment: A New Protocol with Stereophotogrammetric Systems</title><title>Journal of applied biomaterials & functional materials</title><addtitle>J Appl Biomater Funct Mater</addtitle><description>Purpose
A method for the quantification of handwritten spirals in patients with Parkinson's disease (PD) pre and post levodopa treatment is reported.
Methods
Fifteen PD patients (mean age: 66.80±9.75 years) were assessed in the absence of medication (OFF condition) and under levodopa administration (ON condition). The control group was composed of 15 age-matched healthy (H) individuals (mean age: 63.70±9.40). They were asked to hand draw a spiral at self-selected speed, without resting their forearm on the table. The participants drew on a paper sheet, using a normal pen. The trace of the pen was determined from the 3D coordinates of passive markers placed on the pen and on the sheet, acquired with an optoelectronic system and some parameters were identified and computed.
Results
The method revealed to be significant in highlighting the differences between H and PD subjects and in detecting pharmacologic effect. PD patients are impaired in spiral drawing execution and levodopa improves drawing performance, evidenced by spatio-temporal parameters and velocity profiles.
Conclusions
The protocol is easily employable in clinic analysis because of its simplicity, the short duration of the test, and the natural test conditions. These characteristics suggest the applicability of this protocol to other fields of motor and cognitive assessments.</description><subject>Adult</subject><subject>Aged</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - physiopathology</subject><subject>Photogrammetry</subject><subject>Severity of Illness Index</subject><issn>2280-8000</issn><issn>2280-8000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9P3DAQxa2KqiDKubfKNzh0F9tZ5w-3FS1QadUiLT1bE2cM3iZx6nGK9jPwpcmytOqlp3ka_eZJ8x5jH6SY60zI8w3UrpsrIdW8Url-w46UKsWsFEIc_KMP2QnRZhKilHmls3fsUKmiKlUmj9jTevARWr7sod2SJ-57vh7rDdpE_NGnB34L8afvKfSnxD97QiDkNboQkUPfcHAJI1_h79CEAfhdREgd9umCL_k3fOS3MaRgQ7s3W08whuFh2t1H6DpM0Vu-3lLCjt6ztw5awpPXecx-XH25u7yZrb5ff71crmZW5zLNCtdkBSgtysblsspdXRbalY22UAmhQBT5QutM6kJLWdaVmJ5eaFvXmbMLtbDZMTvb-w4x_BqRkuk8WWxb6DGMZKTOhS6qXKoJPd-jNgaiiM4M0XcQt0YKsyvBvJRgdiWYXQnTxcdX87HusPnL_4l8Aj7tAYJ7NJswxil6-q_fM3b9kns</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Galli, Manuela</creator><creator>Vimercati, Sara L.</creator><creator>Manetti, Elena</creator><creator>Cimolin, Veronica</creator><creator>Albertini, Giorgio</creator><creator>De Pandis, Maria F.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Spiral Analysis in Subjects with Parkinson's Disease before and after Levodopa Treatment: A New Protocol with Stereophotogrammetric Systems</title><author>Galli, Manuela ; Vimercati, Sara L. ; Manetti, Elena ; Cimolin, Veronica ; Albertini, Giorgio ; De Pandis, Maria F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-7fd37a2508df6196fb875f8d5ca9002a07645531575118b9069545cbb3fc424c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antiparkinson Agents - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Levodopa - therapeutic use</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parkinson Disease - drug therapy</topic><topic>Parkinson Disease - physiopathology</topic><topic>Photogrammetry</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galli, Manuela</creatorcontrib><creatorcontrib>Vimercati, Sara L.</creatorcontrib><creatorcontrib>Manetti, Elena</creatorcontrib><creatorcontrib>Cimolin, Veronica</creatorcontrib><creatorcontrib>Albertini, Giorgio</creatorcontrib><creatorcontrib>De Pandis, Maria F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied biomaterials & functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Galli, Manuela</au><au>Vimercati, Sara L.</au><au>Manetti, Elena</au><au>Cimolin, Veronica</au><au>Albertini, Giorgio</au><au>De Pandis, Maria F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spiral Analysis in Subjects with Parkinson's Disease before and after Levodopa Treatment: A New Protocol with Stereophotogrammetric Systems</atitle><jtitle>Journal of applied biomaterials & functional materials</jtitle><addtitle>J Appl Biomater Funct Mater</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>12</volume><issue>2</issue><spage>107</spage><epage>112</epage><pages>107-112</pages><issn>2280-8000</issn><eissn>2280-8000</eissn><abstract>Purpose
A method for the quantification of handwritten spirals in patients with Parkinson's disease (PD) pre and post levodopa treatment is reported.
Methods
Fifteen PD patients (mean age: 66.80±9.75 years) were assessed in the absence of medication (OFF condition) and under levodopa administration (ON condition). The control group was composed of 15 age-matched healthy (H) individuals (mean age: 63.70±9.40). They were asked to hand draw a spiral at self-selected speed, without resting their forearm on the table. The participants drew on a paper sheet, using a normal pen. The trace of the pen was determined from the 3D coordinates of passive markers placed on the pen and on the sheet, acquired with an optoelectronic system and some parameters were identified and computed.
Results
The method revealed to be significant in highlighting the differences between H and PD subjects and in detecting pharmacologic effect. PD patients are impaired in spiral drawing execution and levodopa improves drawing performance, evidenced by spatio-temporal parameters and velocity profiles.
Conclusions
The protocol is easily employable in clinic analysis because of its simplicity, the short duration of the test, and the natural test conditions. These characteristics suggest the applicability of this protocol to other fields of motor and cognitive assessments.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22798231</pmid><doi>10.5301/jabfm.2012.9265</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | SAGE Journals |
| subjects | Adult Aged Antiparkinson Agents - therapeutic use Female Humans Levodopa - therapeutic use Linear Models Male Middle Aged Parkinson Disease - drug therapy Parkinson Disease - physiopathology Photogrammetry Severity of Illness Index |
| title | Spiral Analysis in Subjects with Parkinson's Disease before and after Levodopa Treatment: A New Protocol with Stereophotogrammetric Systems |
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