Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

Epithelial-to-mesenchymal transition (EMT) facilitates the escape of pancreatic cancer cells from the primary tumor site, which is a key early event in metastasis. In the present study, we examined if intermittent hypoxia facilitates the invasiveness of human pancreatic cancer cell lines (Panc-1 and...

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Veröffentlicht in:	Oncology reports 2014-09, Vol.32 (3), p.935-942
Hauptverfasser:	ZHU, HAITAO, WANG, DONGQING, ZHANG, LIRONG, XIE, XIAODONG, WU, YINGYING, LIU, YANFANG, SHAO, GENBAO, SU, ZHAOLIANG
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Angiogenesis Antigens, CD - metabolism Autophagy Cell adhesion & migration Cell Hypoxia Cell Line, Tumor Cell Movement Epithelial-Mesenchymal Transition Epithelial-to-mesenchymal transition Glycoproteins - metabolism HIF-1α Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunoglobulins Metastasis Neoplasm Metastasis Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pancreatic cancer pancreatic cancer stem cell Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Peptides - metabolism Proteins Studies Tumors Up-Regulation
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