3-Nitropropionic acid produces striatum selective lesions accompanied by iNOS expression

Systemically administered 3-nitropropionic acid (3-NPA) that inhibits the mitochondrial oxidative phosphorylation induces selective lesions in the striatum. To investigate the nature of these selective lesions, we administered 3-NPA (20 mg/kg, s.c. daily for 2 or 3 days) to Wistar rats and investiga...

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Veröffentlicht in:	Journal of chemical neuroanatomy 1996-06, Vol.10 (3), p.209-212
Hauptverfasser:	Nishino, Hitoo, Fujimoto, Ichiro, Shimano, Yasunobu, Hida, Hideki, Kumazaki, Michiko, Fukuda, Atsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Astrocyte Astrocytes - chemistry Behavior, Animal - drug effects Blood-brain barrier Cell Death - drug effects Dyspnea - chemically induced Enzyme Inhibitors - pharmacology Glial Fibrillary Acidic Protein - analysis Guanidines - pharmacology Immunohistochemistry Immunosuppressive Agents - pharmacology Injections, Subcutaneous Male Neostriatum - drug effects Neostriatum - immunology Neostriatum - metabolism Neuritis - chemically induced Neuronal cell death Neurotoxin Neurotoxins - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - immunology Nitric Oxide Synthase - metabolism Nitro Compounds Propionates - pharmacology Rats Rats, Wistar Striatum Tacrolimus - pharmacology
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