Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats

Rationale Several compounds that potentiate GABA-induced inhibitory currents also decrease stress, anxiety and addiction-related behaviors. Because of the well-established connection between stress and addiction, compounds that reduce stress-induced responses might be efficacious in treating addicti...

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Veröffentlicht in:	Psychopharmacology 2014-09, Vol.231 (17), p.3391-3400
Hauptverfasser:	Schmoutz, Christopher D., Runyon, Scott P, Goeders, Nicholas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cocaine - pharmacology Cocaine abuse Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - psychology Complications and side effects Cues Dosage and administration Drug addiction Drug interactions Drug-Seeking Behavior - drug effects Extinction, Psychological - drug effects Feeding Behavior - drug effects GABA GABA Agents - therapeutic use Health aspects Identification and classification Male Neurology Neurosciences Neurotransmitter Agents - therapeutic use Original Investigation Pharmacology/Toxicology Psychiatry Psychopharmacology Rats Rats, Wistar Self Administration Steroids Steroids (Drugs) Substance abuse treatment
Online-Zugang:	Volltext
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