DNA Methylation: Roles in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an immune-mediated disease of unknown cause that primarily affects the joints and ultimately leads to joint destruction. In recent years, the potential role of DNA methylation in the development of RA is raising great expectations among clinicians and researchers. DNA me...
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| Veröffentlicht in: | Cell biochemistry and biophysics 2014-09, Vol.70 (1), p.77-82 |
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| creator | Yuan, Feng-Lai Li, Xia Xu, Rui-Sheng Jiang, Dong-Lin Zhou, Xiao-Gang |
| description | Rheumatoid arthritis (RA) is an immune-mediated disease of unknown cause that primarily affects the joints and ultimately leads to joint destruction. In recent years, the potential role of DNA methylation in the development of RA is raising great expectations among clinicians and researchers. DNA methylation influences diverse aspects of the disease and regulates epigenetic silencing of genes and behavior of several cell types, especially fibroblast-like synoviocytes (FLS), the most resident cells in joints. The activation of FLS is generally regarded as a key process in the development of RA that actively results in the promotion of ongoing inflammation and joint damage. It has also been shown that aberrant DNA methylation occurs in the pathogenesis of RA and contributes to the development of the disease. Recently, there has been an impressive increase in studies involving DNA methylation in RA. In this paper, we consider the role of DNA methylation in the development of RA. |
| doi_str_mv | 10.1007/s12013-014-9913-8 |
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In recent years, the potential role of DNA methylation in the development of RA is raising great expectations among clinicians and researchers. DNA methylation influences diverse aspects of the disease and regulates epigenetic silencing of genes and behavior of several cell types, especially fibroblast-like synoviocytes (FLS), the most resident cells in joints. The activation of FLS is generally regarded as a key process in the development of RA that actively results in the promotion of ongoing inflammation and joint damage. It has also been shown that aberrant DNA methylation occurs in the pathogenesis of RA and contributes to the development of the disease. Recently, there has been an impressive increase in studies involving DNA methylation in RA. In this paper, we consider the role of DNA methylation in the development of RA.</description><identifier>ISSN: 1085-9195</identifier><identifier>EISSN: 1559-0283</identifier><identifier>DOI: 10.1007/s12013-014-9913-8</identifier><identifier>PMID: 24652004</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - genetics ; Autoimmune diseases ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biotechnology ; Cell Biology ; Deoxyribonucleic acid ; DNA ; DNA Methylation - drug effects ; Humans ; Life Sciences ; Molecular Targeted Therapy ; Pharmacology/Toxicology ; Review Paper ; Rheumatoid arthritis</subject><ispartof>Cell biochemistry and biophysics, 2014-09, Vol.70 (1), p.77-82</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-a313e33221f22acdd2c350c39ce3671901cfa0e12f5e66b5c348dc87eff4c72d3</citedby><cites>FETCH-LOGICAL-c475t-a313e33221f22acdd2c350c39ce3671901cfa0e12f5e66b5c348dc87eff4c72d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12013-014-9913-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12013-014-9913-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24652004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Feng-Lai</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Xu, Rui-Sheng</creatorcontrib><creatorcontrib>Jiang, Dong-Lin</creatorcontrib><creatorcontrib>Zhou, Xiao-Gang</creatorcontrib><title>DNA Methylation: Roles in Rheumatoid Arthritis</title><title>Cell biochemistry and biophysics</title><addtitle>Cell Biochem Biophys</addtitle><addtitle>Cell Biochem Biophys</addtitle><description>Rheumatoid arthritis (RA) is an immune-mediated disease of unknown cause that primarily affects the joints and ultimately leads to joint destruction. 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In recent years, the potential role of DNA methylation in the development of RA is raising great expectations among clinicians and researchers. DNA methylation influences diverse aspects of the disease and regulates epigenetic silencing of genes and behavior of several cell types, especially fibroblast-like synoviocytes (FLS), the most resident cells in joints. The activation of FLS is generally regarded as a key process in the development of RA that actively results in the promotion of ongoing inflammation and joint damage. It has also been shown that aberrant DNA methylation occurs in the pathogenesis of RA and contributes to the development of the disease. Recently, there has been an impressive increase in studies involving DNA methylation in RA. In this paper, we consider the role of DNA methylation in the development of RA.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24652004</pmid><doi>10.1007/s12013-014-9913-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - genetics Autoimmune diseases Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Deoxyribonucleic acid DNA DNA Methylation - drug effects Humans Life Sciences Molecular Targeted Therapy Pharmacology/Toxicology Review Paper Rheumatoid arthritis |
| title | DNA Methylation: Roles in Rheumatoid Arthritis |
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