Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis

Central nervous system (CNS) is an increasingly common site of isolated metastasis for patients with Stage 4 neuroblastoma. To explore the microRNA (miRNA) profile of this metastatic process, miRNA sequencing was performed to identify miRNA sequence families with differential expression between tumo...

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Veröffentlicht in:	Genes chromosomes & cancer 2014-10, Vol.53 (10), p.803-814
Hauptverfasser:	Cheung, Irene Y., Farazi, Thalia A., Ostrovnaya, Irina, Xu, Hong, Tran, Hoa, Mihailovic, Aleksandra, Tuschl, Thomas, Cheung, Nai-Kong V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - metabolism Cell Line, Tumor Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - metabolism Central Nervous System Neoplasms - secondary Down-Regulation Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Killer Cells, Natural - metabolism MicroRNAs - genetics MicroRNAs - metabolism N-Myc Proto-Oncogene Protein Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Staging Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Nuclear Proteins - metabolism Oncogene Proteins - metabolism Sequence Analysis, RNA T-Lymphocytes - metabolism
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