SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS
SPARC‐like 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the regulation of processes such as cell migration, proliferation, and differentiation. Here we show that SC1 exhibits remarkably diverse and dynamic expression in the developing and adult nervou...
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| Veröffentlicht in: | Journal of comparative neurology (1911) 2012-08, Vol.520 (12), p.2575-2590 |
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| container_title | Journal of comparative neurology (1911) |
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| creator | Lloyd-Burton, Samantha Roskams, A. Jane |
| description | SPARC‐like 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the regulation of processes such as cell migration, proliferation, and differentiation. Here we show that SC1 exhibits remarkably diverse and dynamic expression in the developing and adult nervous system. During development, SC1 localizes to radial glia and pial‐derived structures, including the vasculature, choroid plexus, and pial membranes. SC1 is not downregulated in postnatal development, but its expression shifts to distinct time windows in subtypes of glia and neurons, including astrocytes, large projection neurons, Bergmann glia, Schwann cells, and ganglionic satellite cells. In addition, SC1 expression levels and patterns are not altered in the SPARC null mouse, suggesting that SC1 does not compensate for the absence of SPARC. We conclude that SC1 and SPARC may share significant homology, but are likely to have distinct but complementary roles in nervous system development. J. Comp. Neurol. 520:2575–2590, 2012. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/cne.23029 |
| format | Article |
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We conclude that SC1 and SPARC may share significant homology, but are likely to have distinct but complementary roles in nervous system development. J. Comp. Neurol. 520:2575–2590, 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.23029</identifier><identifier>PMID: 22173850</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>angiogenesis ; Animals ; Calcium-Binding Proteins - deficiency ; Calcium-Binding Proteins - genetics ; Calcium-Binding Proteins - metabolism ; Cerebellum - cytology ; Cerebellum - embryology ; Cerebellum - physiology ; Cerebral Cortex - cytology ; Cerebral Cortex - embryology ; Cerebral Cortex - physiology ; Extracellular Matrix Proteins - deficiency ; Extracellular Matrix Proteins - genetics ; Extracellular Matrix Proteins - metabolism ; Gene Expression Regulation, Developmental - genetics ; hevin ; Indexing terms: SC1 ; matricellular proteins ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Mutant Strains ; Osteonectin - deficiency ; Osteonectin - genetics ; Osteonectin - metabolism ; radial glia ; Sequence Homology, Amino Acid ; SPARC</subject><ispartof>Journal of comparative neurology (1911), 2012-08, Vol.520 (12), p.2575-2590</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4249-b5223b0e86c57c1dca7ae9e7099b49bb2b02c5f4fca98d0569aefa2c5a63193d3</citedby><cites>FETCH-LOGICAL-c4249-b5223b0e86c57c1dca7ae9e7099b49bb2b02c5f4fca98d0569aefa2c5a63193d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcne.23029$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcne.23029$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22173850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lloyd-Burton, Samantha</creatorcontrib><creatorcontrib>Roskams, A. Jane</creatorcontrib><title>SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>SPARC‐like 1 (SC1) is a member of the SPARC family of matricellular proteins that has been implicated in the regulation of processes such as cell migration, proliferation, and differentiation. Here we show that SC1 exhibits remarkably diverse and dynamic expression in the developing and adult nervous system. During development, SC1 localizes to radial glia and pial‐derived structures, including the vasculature, choroid plexus, and pial membranes. SC1 is not downregulated in postnatal development, but its expression shifts to distinct time windows in subtypes of glia and neurons, including astrocytes, large projection neurons, Bergmann glia, Schwann cells, and ganglionic satellite cells. In addition, SC1 expression levels and patterns are not altered in the SPARC null mouse, suggesting that SC1 does not compensate for the absence of SPARC. We conclude that SC1 and SPARC may share significant homology, but are likely to have distinct but complementary roles in nervous system development. J. Comp. Neurol. 520:2575–2590, 2012. © 2012 Wiley Periodicals, Inc.</description><subject>angiogenesis</subject><subject>Animals</subject><subject>Calcium-Binding Proteins - deficiency</subject><subject>Calcium-Binding Proteins - genetics</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Cerebellum - cytology</subject><subject>Cerebellum - embryology</subject><subject>Cerebellum - physiology</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - embryology</subject><subject>Cerebral Cortex - physiology</subject><subject>Extracellular Matrix Proteins - deficiency</subject><subject>Extracellular Matrix Proteins - genetics</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>hevin</subject><subject>Indexing terms: SC1</subject><subject>matricellular proteins</subject><subject>Mice</subject><subject>Mice, 129 Strain</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Mice, Mutant Strains</subject><subject>Osteonectin - deficiency</subject><subject>Osteonectin - genetics</subject><subject>Osteonectin - metabolism</subject><subject>radial glia</subject><subject>Sequence Homology, Amino Acid</subject><subject>SPARC</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokNhwQugK7FpF2n9kzjxskSlBVUDYkBdWo5zA2mTONhJ23mXPiyembYLJMTKuj7fPbpHh5C3jB4xSvmxHfCIC8rVM7JgVMlEFZI9J4uosUQpme-RVyFcUUqVEsVLssc5y0WR0QW5X309-VYmXXuNwOBgVbJDaAMYqNsb9AG7NeDd6DEErMEMNdR4g50bexwm00XV48-5M1NUezP51mLXxdnD6N2E7QDTLzNB7TDA4Cawrh9xCJGHxvkoIpgq4GARXAPbW2C7hFAuV6_Ji8Z0Ad88vPvkx8fT7-V5cvHl7FN5cpHYlKcqqTLORUWxkDbLLautyQ0qzGPaKlVVxSvKbdakjTWqqGkmlcHGxC8jBVOiFvvkYOcbj_49Y5h034ZNEjOgm4NmmaRMFDRN_49STjMmWC4j-v4v9MrNfohBomGabcqRIlKHO8p6F4LHRo--7Y1fRyu9aVfHdvW23ci-e3Ccqx7rJ_Kxzggc74DbtsP1v510uTx9tEx2G22Y8O5pw_hrLXORZ_pyeabPLz-LDyVLtRR_AE8yvHo</recordid><startdate>20120815</startdate><enddate>20120815</enddate><creator>Lloyd-Burton, Samantha</creator><creator>Roskams, A. 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Jane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4249-b5223b0e86c57c1dca7ae9e7099b49bb2b02c5f4fca98d0569aefa2c5a63193d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>angiogenesis</topic><topic>Animals</topic><topic>Calcium-Binding Proteins - deficiency</topic><topic>Calcium-Binding Proteins - genetics</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Cerebellum - cytology</topic><topic>Cerebellum - embryology</topic><topic>Cerebellum - physiology</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - embryology</topic><topic>Cerebral Cortex - physiology</topic><topic>Extracellular Matrix Proteins - deficiency</topic><topic>Extracellular Matrix Proteins - genetics</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>hevin</topic><topic>Indexing terms: SC1</topic><topic>matricellular proteins</topic><topic>Mice</topic><topic>Mice, 129 Strain</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Mice, Mutant Strains</topic><topic>Osteonectin - deficiency</topic><topic>Osteonectin - genetics</topic><topic>Osteonectin - metabolism</topic><topic>radial glia</topic><topic>Sequence Homology, Amino Acid</topic><topic>SPARC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lloyd-Burton, Samantha</creatorcontrib><creatorcontrib>Roskams, A. 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SC1 is not downregulated in postnatal development, but its expression shifts to distinct time windows in subtypes of glia and neurons, including astrocytes, large projection neurons, Bergmann glia, Schwann cells, and ganglionic satellite cells. In addition, SC1 expression levels and patterns are not altered in the SPARC null mouse, suggesting that SC1 does not compensate for the absence of SPARC. We conclude that SC1 and SPARC may share significant homology, but are likely to have distinct but complementary roles in nervous system development. J. Comp. Neurol. 520:2575–2590, 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22173850</pmid><doi>10.1002/cne.23029</doi><tpages>16</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | angiogenesis Animals Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cerebellum - cytology Cerebellum - embryology Cerebellum - physiology Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - physiology Extracellular Matrix Proteins - deficiency Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene Expression Regulation, Developmental - genetics hevin Indexing terms: SC1 matricellular proteins Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Osteonectin - deficiency Osteonectin - genetics Osteonectin - metabolism radial glia Sequence Homology, Amino Acid SPARC |
| title | SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS |
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