iRGD tumor-penetrating peptide-modified oncolytic adenovirus shows enhanced tumor transduction, intratumoral dissemination and antitumor efficacy

Endovenously administered oncolytic viruses extravasate and penetrate poorly into tumors. iRGD is a cyclic peptide that enhances tumor penetration when conjugated or coadministered with different types of molecules such as drugs, nanoparticles or phages. iRGD-mediated tumor penetration occurs in thr...

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Veröffentlicht in:	Gene therapy 2014-08, Vol.21 (8), p.767-774
Hauptverfasser:	Puig-Saus, C, Rojas, L A, Laborda, E, Figueras, A, Alba, R, Fillat, C, Alemany, R
Format:	Artikel
Sprache:	eng
Schlagworte:	42 42/41 42/44 692/699/67 Adenovirus Adenoviruses Amino Acid Motifs Animals Antitumor activity Biomedical and Life Sciences Biomedicine C-Terminus Cancer Care and treatment Cell Biology Cell Line, Tumor Cytotoxicity Drug Delivery Systems - methods Extravasation Female Gene Expression Gene Therapy Genetic Therapy - methods Genetic vectors Health aspects HEK293 Cells Human Genetics Human Umbilical Vein Endothelial Cells Humans Integrins Internalization MCF-7 Cells Mice, Inbred BALB C Nanoparticles Nanotechnology Neuropilin Neuropilin-1 - metabolism Oligopeptides - therapeutic use Oncolysis Oncolytic Virotherapy - methods original-article Peptides Phages Proteolysis Spleen Transduction Tumor cells Tumors Virus Internalization Xenograft Model Antitumor Assays
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