Ultrasound Arthroscopy of Human Knee Cartilage and Subchondral Bone in Vivo
Abstract Arthroscopic ultrasound imaging enables quantitative evaluation of articular cartilage. However, the potential of this technique for evaluation of subchondral bone has not been investigated in vivo . In this study, we address this issue in clinical arthroscopy of the human knee (n = 11) by...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2014-09, Vol.40 (9), p.2039-2047 |
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| creator | Liukkonen, Jukka Lehenkari, Petri Hirvasniemi, Jukka Joukainen, Antti Virén, Tuomas Saarakkala, Simo Nieminen, Miika T Jurvelin, Jukka S Töyräs, Juha |
| description | Abstract Arthroscopic ultrasound imaging enables quantitative evaluation of articular cartilage. However, the potential of this technique for evaluation of subchondral bone has not been investigated in vivo . In this study, we address this issue in clinical arthroscopy of the human knee (n = 11) by determining quantitative ultrasound (9 MHz) reflection and backscattering parameters for cartilage and subchondral bone. Furthermore, in each knee, seven anatomical sites were graded using the International Cartilage Repair Society (ICRS) system based on (i) conventional arthroscopy and (ii) ultrasound images acquired in arthroscopy with a miniature transducer. Ultrasound enabled visualization of articular cartilage and subchondral bone. ICRS grades based on ultrasound images were higher ( p |
| doi_str_mv | 10.1016/j.ultrasmedbio.2014.04.001 |
| format | Article |
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However, the potential of this technique for evaluation of subchondral bone has not been investigated in vivo . In this study, we address this issue in clinical arthroscopy of the human knee (n = 11) by determining quantitative ultrasound (9 MHz) reflection and backscattering parameters for cartilage and subchondral bone. Furthermore, in each knee, seven anatomical sites were graded using the International Cartilage Repair Society (ICRS) system based on (i) conventional arthroscopy and (ii) ultrasound images acquired in arthroscopy with a miniature transducer. Ultrasound enabled visualization of articular cartilage and subchondral bone. ICRS grades based on ultrasound images were higher ( p < 0.05) than those based on conventional arthroscopy. The higher ultrasound-based ICRS grades were expected as ultrasound reveals additional information on, for example, the relative depth of the lesion. In line with previous literature, ultrasound reflection and scattering in cartilage varied significantly ( p < 0.05) along the ICRS scale. However, no significant correlation between ultrasound parameters and structure or density of subchondral bone could be demonstrated. To conclude, arthroscopic ultrasound imaging had a significant effect on clinical grading of cartilage, and it was found to provide quantitative information on cartilage. The lack of correlation between the ultrasound parameters and bone properties may be related to lesser bone change or excessive attenuation in overlying cartilage and insufficient power of the applied miniature transducer.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2014.04.001</identifier><identifier>PMID: 25023111</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Aged ; Arthroscopy ; Arthroscopy - methods ; Articular cartilage ; Cartilage, Articular - diagnostic imaging ; Cartilage, Articular - surgery ; Contrast Media ; Feasibility Studies ; Gadolinium DTPA ; High frequency ; Humans ; Imaging ; Imaging, Three-Dimensional - methods ; International Cartilage Repair Society score ; Ioxaglic Acid ; Knee ; Knee - diagnostic imaging ; Knee - surgery ; Knee Joint - diagnostic imaging ; Knee Joint - surgery ; Middle Aged ; Osteoarthritis ; Preoperative Care - methods ; Radiographic Image Enhancement - methods ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Subchondral bone ; Tomography, X-Ray Computed - methods ; Ultrasonography ; Ultrasound</subject><ispartof>Ultrasound in medicine & biology, 2014-09, Vol.40 (9), p.2039-2047</ispartof><rights>World Federation for Ultrasound in Medicine & Biology</rights><rights>2014 World Federation for Ultrasound in Medicine & Biology</rights><rights>Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-758ab510ce431a3c70caa71d37a3b0d31a609cc8737de7e1dc1cdb245addcd7d3</citedby><cites>FETCH-LOGICAL-c567t-758ab510ce431a3c70caa71d37a3b0d31a609cc8737de7e1dc1cdb245addcd7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2014.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25023111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liukkonen, Jukka</creatorcontrib><creatorcontrib>Lehenkari, Petri</creatorcontrib><creatorcontrib>Hirvasniemi, Jukka</creatorcontrib><creatorcontrib>Joukainen, Antti</creatorcontrib><creatorcontrib>Virén, Tuomas</creatorcontrib><creatorcontrib>Saarakkala, Simo</creatorcontrib><creatorcontrib>Nieminen, Miika T</creatorcontrib><creatorcontrib>Jurvelin, Jukka S</creatorcontrib><creatorcontrib>Töyräs, Juha</creatorcontrib><title>Ultrasound Arthroscopy of Human Knee Cartilage and Subchondral Bone in Vivo</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>Abstract Arthroscopic ultrasound imaging enables quantitative evaluation of articular cartilage. However, the potential of this technique for evaluation of subchondral bone has not been investigated in vivo . In this study, we address this issue in clinical arthroscopy of the human knee (n = 11) by determining quantitative ultrasound (9 MHz) reflection and backscattering parameters for cartilage and subchondral bone. Furthermore, in each knee, seven anatomical sites were graded using the International Cartilage Repair Society (ICRS) system based on (i) conventional arthroscopy and (ii) ultrasound images acquired in arthroscopy with a miniature transducer. Ultrasound enabled visualization of articular cartilage and subchondral bone. ICRS grades based on ultrasound images were higher ( p < 0.05) than those based on conventional arthroscopy. The higher ultrasound-based ICRS grades were expected as ultrasound reveals additional information on, for example, the relative depth of the lesion. In line with previous literature, ultrasound reflection and scattering in cartilage varied significantly ( p < 0.05) along the ICRS scale. However, no significant correlation between ultrasound parameters and structure or density of subchondral bone could be demonstrated. To conclude, arthroscopic ultrasound imaging had a significant effect on clinical grading of cartilage, and it was found to provide quantitative information on cartilage. The lack of correlation between the ultrasound parameters and bone properties may be related to lesser bone change or excessive attenuation in overlying cartilage and insufficient power of the applied miniature transducer.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthroscopy</subject><subject>Arthroscopy - methods</subject><subject>Articular cartilage</subject><subject>Cartilage, Articular - diagnostic imaging</subject><subject>Cartilage, Articular - surgery</subject><subject>Contrast Media</subject><subject>Feasibility Studies</subject><subject>Gadolinium DTPA</subject><subject>High frequency</subject><subject>Humans</subject><subject>Imaging</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>International Cartilage Repair Society score</subject><subject>Ioxaglic Acid</subject><subject>Knee</subject><subject>Knee - diagnostic imaging</subject><subject>Knee - surgery</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - surgery</subject><subject>Middle Aged</subject><subject>Osteoarthritis</subject><subject>Preoperative Care - methods</subject><subject>Radiographic Image Enhancement - methods</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Subchondral bone</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ultrasonography</subject><subject>Ultrasound</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktGKEzEUhoMobq2-ggxeeTP1nGQyab0Q1uq6YsGLdcW7kElO3dRp0k1mFvo2-yw-maldRbxaOBBIvvw_fBzGXiDMELB9tZmN_ZBM3pLrfJxxwGYGZQAfsAnO1aLmC_z2kE1AANay5YsT9iTnDQCoVqjH7IRL4AIRJ2x1-TsqjsFVp2m4SjHbuNtXcV2dj1sTqk-BqFqaNPjefKfKFO5i7OxVDC6ZvnobA1U-_Lz96m_iU_ZobfpMz-7OKbs8e_9leV6vPn_4uDxd1Va2aqiVnJtOIlhqBBphFVhjFDqhjOjAlbsWFtbOlVCOFKGzaF3HG2mcs045MWUvj7m7FK9HyoPe-myp702gOGaNsgUUjeLqHqjkc2hkAwV9fURtkZATrfUu-a1Je42gD-L1Rv8rXh_EayhTyqbs-V3P2JXnv1__mC7AuyNARcyNp6Sz9RQsOZ_IDtpFf7-eN__F2N4Hb03_g_aUN3FMoajXqDPXoC8OK3DYAGwAeINS_AIunbD9</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Liukkonen, Jukka</creator><creator>Lehenkari, Petri</creator><creator>Hirvasniemi, Jukka</creator><creator>Joukainen, Antti</creator><creator>Virén, Tuomas</creator><creator>Saarakkala, Simo</creator><creator>Nieminen, Miika T</creator><creator>Jurvelin, Jukka S</creator><creator>Töyräs, Juha</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20140901</creationdate><title>Ultrasound Arthroscopy of Human Knee Cartilage and Subchondral Bone in Vivo</title><author>Liukkonen, Jukka ; Lehenkari, Petri ; Hirvasniemi, Jukka ; Joukainen, Antti ; Virén, Tuomas ; Saarakkala, Simo ; Nieminen, Miika T ; Jurvelin, Jukka S ; Töyräs, Juha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-758ab510ce431a3c70caa71d37a3b0d31a609cc8737de7e1dc1cdb245addcd7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthroscopy</topic><topic>Arthroscopy - methods</topic><topic>Articular cartilage</topic><topic>Cartilage, Articular - diagnostic imaging</topic><topic>Cartilage, Articular - surgery</topic><topic>Contrast Media</topic><topic>Feasibility Studies</topic><topic>Gadolinium DTPA</topic><topic>High frequency</topic><topic>Humans</topic><topic>Imaging</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>International Cartilage Repair Society score</topic><topic>Ioxaglic Acid</topic><topic>Knee</topic><topic>Knee - diagnostic imaging</topic><topic>Knee - surgery</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - surgery</topic><topic>Middle Aged</topic><topic>Osteoarthritis</topic><topic>Preoperative Care - methods</topic><topic>Radiographic Image Enhancement - methods</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Subchondral bone</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Ultrasonography</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liukkonen, Jukka</creatorcontrib><creatorcontrib>Lehenkari, Petri</creatorcontrib><creatorcontrib>Hirvasniemi, Jukka</creatorcontrib><creatorcontrib>Joukainen, Antti</creatorcontrib><creatorcontrib>Virén, Tuomas</creatorcontrib><creatorcontrib>Saarakkala, Simo</creatorcontrib><creatorcontrib>Nieminen, Miika T</creatorcontrib><creatorcontrib>Jurvelin, Jukka S</creatorcontrib><creatorcontrib>Töyräs, Juha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liukkonen, Jukka</au><au>Lehenkari, Petri</au><au>Hirvasniemi, Jukka</au><au>Joukainen, Antti</au><au>Virén, Tuomas</au><au>Saarakkala, Simo</au><au>Nieminen, Miika T</au><au>Jurvelin, Jukka S</au><au>Töyräs, Juha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound Arthroscopy of Human Knee Cartilage and Subchondral Bone in Vivo</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>40</volume><issue>9</issue><spage>2039</spage><epage>2047</epage><pages>2039-2047</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>Abstract Arthroscopic ultrasound imaging enables quantitative evaluation of articular cartilage. However, the potential of this technique for evaluation of subchondral bone has not been investigated in vivo . In this study, we address this issue in clinical arthroscopy of the human knee (n = 11) by determining quantitative ultrasound (9 MHz) reflection and backscattering parameters for cartilage and subchondral bone. Furthermore, in each knee, seven anatomical sites were graded using the International Cartilage Repair Society (ICRS) system based on (i) conventional arthroscopy and (ii) ultrasound images acquired in arthroscopy with a miniature transducer. Ultrasound enabled visualization of articular cartilage and subchondral bone. ICRS grades based on ultrasound images were higher ( p < 0.05) than those based on conventional arthroscopy. The higher ultrasound-based ICRS grades were expected as ultrasound reveals additional information on, for example, the relative depth of the lesion. In line with previous literature, ultrasound reflection and scattering in cartilage varied significantly ( p < 0.05) along the ICRS scale. However, no significant correlation between ultrasound parameters and structure or density of subchondral bone could be demonstrated. To conclude, arthroscopic ultrasound imaging had a significant effect on clinical grading of cartilage, and it was found to provide quantitative information on cartilage. The lack of correlation between the ultrasound parameters and bone properties may be related to lesser bone change or excessive attenuation in overlying cartilage and insufficient power of the applied miniature transducer.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>25023111</pmid><doi>10.1016/j.ultrasmedbio.2014.04.001</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Arthroscopy Arthroscopy - methods Articular cartilage Cartilage, Articular - diagnostic imaging Cartilage, Articular - surgery Contrast Media Feasibility Studies Gadolinium DTPA High frequency Humans Imaging Imaging, Three-Dimensional - methods International Cartilage Repair Society score Ioxaglic Acid Knee Knee - diagnostic imaging Knee - surgery Knee Joint - diagnostic imaging Knee Joint - surgery Middle Aged Osteoarthritis Preoperative Care - methods Radiographic Image Enhancement - methods Radiology Reproducibility of Results Sensitivity and Specificity Subchondral bone Tomography, X-Ray Computed - methods Ultrasonography Ultrasound |
| title | Ultrasound Arthroscopy of Human Knee Cartilage and Subchondral Bone in Vivo |
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