Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

Several recent studies have shown that activation of the RhoA/Rho-associated kinase (ROCK) pathway is involved in the MPTP-induced dopaminergic cell degeneration and possibly in Parkinson's disease. ROCK inhibitors have been suggested as candidate neuroprotective drugs for Parkinson's dise...

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Veröffentlicht in:	Neuropharmacology 2014-10, Vol.85, p.1-8
Hauptverfasser:	Borrajo, Ana, Rodriguez-Perez, Ana I., Villar-Cheda, Begoña, Guerra, Maria J., Labandeira-Garcia, Jose L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Axons - drug effects Axons - pathology Axons - physiology Cell Culture Techniques Cell Death - drug effects Cell Death - physiology Cell Line, Tumor Cells, Cultured Dopamine Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Dopaminergic Neurons - physiology Mesencephalon - drug effects Mesencephalon - pathology Mesencephalon - physiopathology Microglia Microglia - drug effects Microglia - enzymology MPTP Poisoning - drug therapy MPTP Poisoning - pathology MPTP Poisoning - physiopathology Neurites - drug effects Neurites - pathology Neurites - physiology Neuroinflammation Neuroprotection Neuroprotective Agents - pharmacology Parkinson Pyridines - pharmacology Rats Rho rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism
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