Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei

•A C-type lectin LvCTL3 from Litopenaeus vannamei.•NF-κB signaling pathway regulates expression of LvCTL3.•LvCTL3 shows different agglutination activities for different bacteria.•LvCTL3 inhibits bacterial or viral infection in vivo. C-type lectins (CTLs) play crucial roles in innate immune responses...

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Veröffentlicht in:	Developmental and comparative immunology 2014-10, Vol.46 (2), p.231-240
Hauptverfasser:	Li, Ming, Li, Chaozheng, Ma, Chunxia, Li, Haoyang, Zuo, Hongliang, Weng, Shaoping, Chen, Xiaohan, Zeng, Digang, He, Jianguo, Xu, Xiaopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglutination Amino Acid Sequence Animals Anti-Bacterial Agents - pharmacology Antiviral Agents - pharmacology Arthropod Proteins - biosynthesis Arthropod Proteins - genetics Arthropod Proteins - pharmacology Bacillus subtilis Base Sequence C-type lectin Cells, Cultured Conserved Sequence Decapoda Escherichia coli Hemocytes - immunology Hemocytes - metabolism Host-Pathogen Interactions Immunity, Innate Innate immunity Lectins, C-Type - biosynthesis Lectins, C-Type - genetics Litopenaeus vannamei Molecular Sequence Data NF-kappa B - physiology NF-κB signaling pathway Organ Specificity Penaeidae - genetics Penaeidae - immunology Penaeidae - metabolism Phylogeny Promoter Regions, Genetic Streptococcus agalactiae Up-Regulation - immunology Vibrio alginolyticus Vibrio parahaemolyticus Vibrio parahaemolyticus - drug effects Vibrio parahaemolyticus - immunology White spot syndrome virus White spot syndrome virus 1 - drug effects White spot syndrome virus 1 - immunology WSSV
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