realm of vitamin K dependent proteins: Shifting from coagulation toward calcification
In the past few decades vitamin K has emerged from a single‐function “haemostasis vitamin” to a “multi‐function vitamin.” The use of vitamin K antagonists (VKA) inevitably showed that the inhibition was not restricted to vitamin K dependent coagulation factors but also synthesis of functional extrah...
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| Veröffentlicht in: | Molecular nutrition & food research 2014-08, Vol.58 (8), p.1620-1635 |
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| container_title | Molecular nutrition & food research |
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| creator | Willems, Brecht A. G Vermeer, Cees Reutelingsperger, Chris P. M Schurgers, Leon J |
| description | In the past few decades vitamin K has emerged from a single‐function “haemostasis vitamin” to a “multi‐function vitamin.” The use of vitamin K antagonists (VKA) inevitably showed that the inhibition was not restricted to vitamin K dependent coagulation factors but also synthesis of functional extrahepatic vitamin K dependent proteins (VKDPs), thereby eliciting undesired side effects. Vascular calcification is one of the recently revealed detrimental effects of VKA. The discovery that VKDPs are involved in vascular calcification has propelled our mechanistic understanding of this process and has opened novel avenues for diagnosis and treatment. This review addresses mechanisms of VKDPs and their significance for physiological and pathological calcification. |
| doi_str_mv | 10.1002/mnfr.201300743 |
| format | Article |
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G</creatorcontrib><creatorcontrib>Vermeer, Cees</creatorcontrib><creatorcontrib>Reutelingsperger, Chris P. M</creatorcontrib><creatorcontrib>Schurgers, Leon J</creatorcontrib><title>realm of vitamin K dependent proteins: Shifting from coagulation toward calcification</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>In the past few decades vitamin K has emerged from a single‐function “haemostasis vitamin” to a “multi‐function vitamin.” The use of vitamin K antagonists (VKA) inevitably showed that the inhibition was not restricted to vitamin K dependent coagulation factors but also synthesis of functional extrahepatic vitamin K dependent proteins (VKDPs), thereby eliciting undesired side effects. Vascular calcification is one of the recently revealed detrimental effects of VKA. 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| subjects | adverse effects Animals antagonists Anticoagulants - pharmacology Anticoagulants - therapeutic use Biomedical Research - trends Blood Coagulation - drug effects calcification Calcification, Physiologic - drug effects Calcinosis - etiology Calcinosis - prevention & control Calcinosis - therapy coagulation Gla-rich protein hemostasis Humans Matrix Gla protein Models, Biological Osteocalcin proteins Vascular calcification Vitamin K Vitamin K - antagonists & inhibitors Vitamin K - metabolism Vitamin K - therapeutic use Vitamin K Deficiency - metabolism Vitamin K Deficiency - physiopathology Vitamin K Deficiency - therapy |
| title | realm of vitamin K dependent proteins: Shifting from coagulation toward calcification |
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