IL-15 improves the cytotoxicity of cytokine-induced killer cells against leukemia cells by upregulating CD3+CD56+ cells and downregulating regulatory T cells as well as IL-35

Cytokine-induced killer (CIK) cells are usually generated from peripheral blood mononuclear cells with the stimulation of IL-2 in vitro. Unlike the conventional IL-2-stimulated CIK cells (IL-2-CIK cells), we investigated the characteristics and potential mechanism of IL-15-stimulated CIK cells (IL-1...

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Veröffentlicht in:	Journal of immunotherapy (1997) 2013-11, Vol.36 (9), p.462-467
Hauptverfasser:	Tao, Qianshan, Chen, Tianping, Tao, Lili, Wang, Huiping, Pan, Ying, Xiong, Shudao, Zhai, Zhimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult CD3 Complex - immunology CD3 Complex - metabolism CD56 Antigen - immunology CD56 Antigen - metabolism Cells, Cultured Cytokine-Induced Killer Cells - immunology Cytotoxicity, Immunologic - drug effects Cytotoxicity, Immunologic - immunology Down-Regulation - drug effects Down-Regulation - immunology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression - drug effects Gene Expression - immunology Humans Interleukin-15 - immunology Interleukin-15 - pharmacology Interleukin-2 - immunology Interleukin-2 - pharmacology Interleukins - genetics Interleukins - immunology Interleukins - metabolism K562 Cells Leukemia - immunology Leukemia - pathology Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Up-Regulation - drug effects Up-Regulation - immunology
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