Prevention of hypoxic pulmonary hypertension by hypoxia-inducible expression of p27 in pulmonary artery smooth muscle cells

Hypoxia-induced proliferation of pulmonary artery smooth muscle cells (SMCs) is important in the development of hypoxic pulmonary hypertension (HPH). We constructed a lentivirial vector containing a smooth muscle-specific promoter and six copies of hypoxia response element to co-drive the expression...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2014-08, Vol.21 (8), p.751-758
Hauptverfasser:	Luo, Y, Zhang, B, Dong, H-Y, Liu, Y, Li, Z-C, Dong, M-Q, Gao, Y-Q
Format:	Artikel
Sprache:	eng
Schlagworte:	42/44 692/699/75 Animals Biomedical and Life Sciences Biomedicine Blood pressure Cell Biology Cell cycle Cell Cycle - genetics Cell Proliferation Cells, Cultured Cyclin-dependent kinase Cyclin-dependent kinase inhibitor p27 Cyclin-dependent kinases Enzyme inhibitors G1 phase G1 Phase Cell Cycle Checkpoints - genetics Gene Expression Gene Therapy Genetic aspects Genetic Therapy Genetic Vectors Heart Human Genetics Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - prevention & control Hypoxia Hypoxia - genetics Hypoxia - metabolism Lentivirus - genetics Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - metabolism Nanotechnology original-article Phase transitions Prevention Proliferating Cell Nuclear Antigen - metabolism Properties Pulmonary arteries Pulmonary artery Pulmonary hypertension Rats Rodents S phase Smooth muscle Veins & arteries Ventricle Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!