Lipopolysaccharide extracted from Porphyromonas gingivalis induces DNA hypermethylation of runt-related transcription factor 2 in human periodontal fibroblasts

Background/Purpose Epigenetic alterations such as DNA methylation and histone acetylation are described as changes in the pattern of gene expression not involving the DNA sequence. Lipopolysaccharide (LPS) derived from Porphyromonas gingivalis has been shown to inhibit osteoblastic cell differentiat...

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Veröffentlicht in:	Journal of microbiology, immunology and infection immunology and infection, 2014-06, Vol.47 (3), p.176-181
Hauptverfasser:	Uehara, Osamu, Abiko, Yoshihiro, Saitoh, Masato, Miyakawa, Hiroshi, Nakazawa, Futoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - drug effects Cells, Cultured Core Binding Factor Alpha 1 Subunit - chemistry Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism DNA Methylation - drug effects Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Host-Pathogen Interactions Humans Infectious Disease Lipopolysaccharide Lipopolysaccharides - pharmacology Medical Education Methylation Osteoblastic differentiation Osteoblasts - cytology Osteoblasts - drug effects Periodontal fibroblast Periodontium - cytology Porphyromonas gingivalis Porphyromonas gingivalis - chemistry Runt-related transcription factor 2
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