Investigating the Potential Role of Persistent Organic Pollutants in Hawaiian Green Sea Turtle Fibropapillomatosis
It has been hypothesized for decades that environmental pollutants may contribute to green sea turtle fibropapillomatosis (FP), possibly through immunosuppression leading to greater susceptibility to the herpesvirus, the putative causative agent of this tumor-forming disease. To address this questio...
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| Veröffentlicht in: | Environmental science & technology 2014-07, Vol.48 (14), p.7807-7816 |
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| creator | Keller, Jennifer M Balazs, George H Nilsen, Frances Rice, Marc Work, Thierry M Jensen, Brenda A |
| description | It has been hypothesized for decades that environmental pollutants may contribute to green sea turtle fibropapillomatosis (FP), possibly through immunosuppression leading to greater susceptibility to the herpesvirus, the putative causative agent of this tumor-forming disease. To address this question, we measured concentrations of 164 persistent organic pollutants (POPs) and halogenated phenols in 53 Hawaiian green turtle (Chelonia mydas) plasma samples archived by the Biological and Environmental Monitoring and Archival of Sea Turtle Tissues (BEMAST) project at the National Institute of Standards and Technology Marine Environmental Specimen Bank. Four groups of turtles were examined: free-ranging turtles from Kiholo Bay (0% FP, Hawaii), Kailua Bay (low FP, 8%, Oahu), and Kapoho Bay (moderate FP, 38%, Hawaii) and severely tumored stranded turtles that required euthanasia (high FP, 100%, Main Hawaiian Islands). Four classes of POPs and seven halogenated phenols were detected in at least one of the turtles, and concentrations were low (often |
| doi_str_mv | 10.1021/es5014054 |
| format | Article |
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To address this question, we measured concentrations of 164 persistent organic pollutants (POPs) and halogenated phenols in 53 Hawaiian green turtle (Chelonia mydas) plasma samples archived by the Biological and Environmental Monitoring and Archival of Sea Turtle Tissues (BEMAST) project at the National Institute of Standards and Technology Marine Environmental Specimen Bank. Four groups of turtles were examined: free-ranging turtles from Kiholo Bay (0% FP, Hawaii), Kailua Bay (low FP, 8%, Oahu), and Kapoho Bay (moderate FP, 38%, Hawaii) and severely tumored stranded turtles that required euthanasia (high FP, 100%, Main Hawaiian Islands). Four classes of POPs and seven halogenated phenols were detected in at least one of the turtles, and concentrations were low (often <200 pg/g wet mass). The presence of halogenated phenols in sea turtles is a novel discovery; their concentrations were higher than most man-made POPs, suggesting that the source of most of these compounds was likely natural (produced by the algal turtle diet) rather than metabolites of man-made POPs. None of the compounds measured increased in concentration with increasing prevalence of FP across the four groups of turtles, suggesting that these 164 compounds are not likely primary triggers for the onset of FP. However, the stranded, severely tumored, emaciated turtle group (n = 14) had the highest concentrations of POPs, which might suggest that mobilization of contaminants with lipids into the blood during late-stage weight loss could contribute to the progression of the disease. Taken together, these data suggest that POPs are not a major cofactor in causing the onset of FP.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es5014054</identifier><identifier>PMID: 24963745</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Chelonia mydas ; Chemical Fractionation ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Environmental Monitoring ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Fundamental and applied biological sciences. Psychology ; Geography ; Hawaii ; Herpes viruses ; Herpesvirus ; Organic Chemicals - blood ; Organic Chemicals - toxicity ; Papilloma - blood ; Papilloma - veterinary ; Phenols ; Pollutants ; Reptiles & amphibians ; Reptilia. Amphibia ; Tumors ; Turtles - blood</subject><ispartof>Environmental science & technology, 2014-07, Vol.48 (14), p.7807-7816</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Chemical Society Jul 15, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a406t-c5a31782819c5ce5936376f55dbab860900e5533f44261386defd85a4df33fd3</citedby><cites>FETCH-LOGICAL-a406t-c5a31782819c5ce5936376f55dbab860900e5533f44261386defd85a4df33fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es5014054$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es5014054$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28691232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24963745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keller, Jennifer M</creatorcontrib><creatorcontrib>Balazs, George H</creatorcontrib><creatorcontrib>Nilsen, Frances</creatorcontrib><creatorcontrib>Rice, Marc</creatorcontrib><creatorcontrib>Work, Thierry M</creatorcontrib><creatorcontrib>Jensen, Brenda A</creatorcontrib><title>Investigating the Potential Role of Persistent Organic Pollutants in Hawaiian Green Sea Turtle Fibropapillomatosis</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>It has been hypothesized for decades that environmental pollutants may contribute to green sea turtle fibropapillomatosis (FP), possibly through immunosuppression leading to greater susceptibility to the herpesvirus, the putative causative agent of this tumor-forming disease. To address this question, we measured concentrations of 164 persistent organic pollutants (POPs) and halogenated phenols in 53 Hawaiian green turtle (Chelonia mydas) plasma samples archived by the Biological and Environmental Monitoring and Archival of Sea Turtle Tissues (BEMAST) project at the National Institute of Standards and Technology Marine Environmental Specimen Bank. Four groups of turtles were examined: free-ranging turtles from Kiholo Bay (0% FP, Hawaii), Kailua Bay (low FP, 8%, Oahu), and Kapoho Bay (moderate FP, 38%, Hawaii) and severely tumored stranded turtles that required euthanasia (high FP, 100%, Main Hawaiian Islands). Four classes of POPs and seven halogenated phenols were detected in at least one of the turtles, and concentrations were low (often <200 pg/g wet mass). The presence of halogenated phenols in sea turtles is a novel discovery; their concentrations were higher than most man-made POPs, suggesting that the source of most of these compounds was likely natural (produced by the algal turtle diet) rather than metabolites of man-made POPs. None of the compounds measured increased in concentration with increasing prevalence of FP across the four groups of turtles, suggesting that these 164 compounds are not likely primary triggers for the onset of FP. However, the stranded, severely tumored, emaciated turtle group (n = 14) had the highest concentrations of POPs, which might suggest that mobilization of contaminants with lipids into the blood during late-stage weight loss could contribute to the progression of the disease. Taken together, these data suggest that POPs are not a major cofactor in causing the onset of FP.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Chelonia mydas</subject><subject>Chemical Fractionation</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geography</subject><subject>Hawaii</subject><subject>Herpes viruses</subject><subject>Herpesvirus</subject><subject>Organic Chemicals - blood</subject><subject>Organic Chemicals - toxicity</subject><subject>Papilloma - blood</subject><subject>Papilloma - veterinary</subject><subject>Phenols</subject><subject>Pollutants</subject><subject>Reptiles & amphibians</subject><subject>Reptilia. Amphibia</subject><subject>Tumors</subject><subject>Turtles - blood</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0V1rFDEUBuAgFrtWL_wDEhBBL0bzdWYyl6XYDyi06F54N5zNZNaUbLImGUv_vVm6tqI3vQocnrzJyyHkDWefOBP8s83AuGKgnpEFB8Ea0MCfkwVjXDa9bL8fkpc53zDGhGT6BTkUqm9lp2BB0kX4ZXNxaywurGn5Yel1LDYUh55-jd7SONFrm7LLuym9SmsMzlTk_VwwlExdoOd4i85hoGfJ2kC_WaTLOZV6-9StUtzi1nkfN1hizXlFDib02b7en0dkefpleXLeXF6dXZwcXzaoWFsaAyh5p4XmvQFjofaQXTsBjCtc6Zb1jFkAKSelRMulbkc7jRpQjVMdjvKIfLiP3ab4c64dh43LxnqPwcY5DxxaxoXshXwCVaCEAq0qffcPvYlzCrXHTnWgOwa7wI_3yqSYc7LTsE1ug-lu4GzYrWx4WFm1b_eJ82pjxwf5Z0cVvN8DzAb9lDAYlx-dbvvaQzw6NPmvX_334G9muajb</recordid><startdate>20140715</startdate><enddate>20140715</enddate><creator>Keller, Jennifer M</creator><creator>Balazs, George H</creator><creator>Nilsen, Frances</creator><creator>Rice, Marc</creator><creator>Work, Thierry M</creator><creator>Jensen, Brenda A</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>7TN</scope><scope>7TV</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20140715</creationdate><title>Investigating the Potential Role of Persistent Organic Pollutants in Hawaiian Green Sea Turtle Fibropapillomatosis</title><author>Keller, Jennifer M ; Balazs, George H ; Nilsen, Frances ; Rice, Marc ; Work, Thierry M ; Jensen, Brenda A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a406t-c5a31782819c5ce5936376f55dbab860900e5533f44261386defd85a4df33fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Chelonia mydas</topic><topic>Chemical Fractionation</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - toxicity</topic><topic>Fundamental and applied biological sciences. 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Sci. Technol</addtitle><date>2014-07-15</date><risdate>2014</risdate><volume>48</volume><issue>14</issue><spage>7807</spage><epage>7816</epage><pages>7807-7816</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>It has been hypothesized for decades that environmental pollutants may contribute to green sea turtle fibropapillomatosis (FP), possibly through immunosuppression leading to greater susceptibility to the herpesvirus, the putative causative agent of this tumor-forming disease. To address this question, we measured concentrations of 164 persistent organic pollutants (POPs) and halogenated phenols in 53 Hawaiian green turtle (Chelonia mydas) plasma samples archived by the Biological and Environmental Monitoring and Archival of Sea Turtle Tissues (BEMAST) project at the National Institute of Standards and Technology Marine Environmental Specimen Bank. Four groups of turtles were examined: free-ranging turtles from Kiholo Bay (0% FP, Hawaii), Kailua Bay (low FP, 8%, Oahu), and Kapoho Bay (moderate FP, 38%, Hawaii) and severely tumored stranded turtles that required euthanasia (high FP, 100%, Main Hawaiian Islands). Four classes of POPs and seven halogenated phenols were detected in at least one of the turtles, and concentrations were low (often <200 pg/g wet mass). The presence of halogenated phenols in sea turtles is a novel discovery; their concentrations were higher than most man-made POPs, suggesting that the source of most of these compounds was likely natural (produced by the algal turtle diet) rather than metabolites of man-made POPs. None of the compounds measured increased in concentration with increasing prevalence of FP across the four groups of turtles, suggesting that these 164 compounds are not likely primary triggers for the onset of FP. However, the stranded, severely tumored, emaciated turtle group (n = 14) had the highest concentrations of POPs, which might suggest that mobilization of contaminants with lipids into the blood during late-stage weight loss could contribute to the progression of the disease. Taken together, these data suggest that POPs are not a major cofactor in causing the onset of FP.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>24963745</pmid><doi>10.1021/es5014054</doi><tpages>10</tpages></addata></record> |
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| subjects | Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Chelonia mydas Chemical Fractionation Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - toxicity Fundamental and applied biological sciences. Psychology Geography Hawaii Herpes viruses Herpesvirus Organic Chemicals - blood Organic Chemicals - toxicity Papilloma - blood Papilloma - veterinary Phenols Pollutants Reptiles & amphibians Reptilia. Amphibia Tumors Turtles - blood |
| title | Investigating the Potential Role of Persistent Organic Pollutants in Hawaiian Green Sea Turtle Fibropapillomatosis |
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