Synthesis of cyclohexapeptides as antimalarial and anti-trypanosomal agents

Cyclohexapeptide analogs of natural products were obtained in very good yields by a combination of solid-phase peptide synthesis, for the linear peptide, and solution cyclization. The activities against Plasmodium falciparum K1, Trypanosoma brucei brucei and murine macrophages (cell line J774) of th...

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Veröffentlicht in:	MedChemComm 2014, Vol.5 (9), p.1309-1316
Hauptverfasser:	Peña, S., Fagundez, C., Medeiros, A., Comini, M., Scarone, L., Sellanes, D., Manta, E., Tulla-Puche, J., Albericio, F., Stewart, L., Yardley, V., Serra, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Plasmodium falciparum Trypanosoma brucei brucei
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