Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector

A stable packaging cell line (Vero/BC-F) constitutively expressing fusion (F) protein of the human parainfluenza virus type 2 (hPIV2) was established for production of the F -defective and single round-infectious hPIV2 vector in a strategy for recombinant vaccine development. The F gene expression h...

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Veröffentlicht in:	Gene therapy 2014-08, Vol.21 (8), p.775-784
Hauptverfasser:	Ohtsuka, J, Fukumura, M, Tsurudome, M, Hara, K, Nishio, M, Kawano, M, Nosaka, T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/1868 631/326/596/2561 692/700/565/201 Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell culture Cell Line Cells, Cultured Cercopithecus aethiops Composition Cricetinae Cytotoxicity Exo-a-sialidase F gene F protein Fusion protein Gene Expression Gene Therapy Gene Transfer Techniques Genetic Vectors Hemagglutinins Human Genetics Humans Infectivity Influenza A Influenza A virus Influenza A virus - genetics Influenza vaccines Lung cancer Nanotechnology original-article Packaging Parainfluenza Parainfluenza virus Parainfluenza Virus 2, Human - genetics Properties Proteins Recombinant Proteins - genetics Tissue culture Transgenes Vaccine development Vaccines Vaccines, Synthetic - genetics Vero Cells Viral Fusion Proteins - genetics Viral Fusion Proteins - metabolism Viral Matrix Proteins - genetics Viruses
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