T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation

Background Wiskott-Aldrich syndrome protein (WASP) links T-cell receptor (TCR) signaling to the actin cytoskeleton. WASP is normally protected from degradation by the Ca++ -dependent protease calpain and by the proteasome because of its interaction with the WASP-interacting protein. Objective We inv...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-09, Vol.132 (3), p.648-655.e1
Hauptverfasser:	Watanabe, Yuko, MD, PhD, Sasahara, Yoji, MD, PhD, Ramesh, Narayanaswamy, PhD, Massaad, Michel J., PhD, Yeng Looi, Chung, PhD, Kumaki, Satoru, MD, PhD, Kure, Shigeo, MD, PhD, Geha, Raif S., MD, Tsuchiya, Shigeru, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptor Proteins, Signal Transducing - metabolism Allergy and Immunology Animals Biological and medical sciences calpain Calpain - antagonists & inhibitors Calpain - metabolism Cbl family proteins Cell Line Cells, Cultured Cysteine Proteinase Inhibitors - pharmacology Cytoskeleton Dipeptides - pharmacology Down-Regulation F-actin Fundamental and applied biological sciences. Psychology Fundamental immunology Hematologic and hematopoietic diseases Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Kinases Leupeptins - pharmacology Medical sciences Mice Mice, Knockout Mutation Platelet diseases and coagulopathies proteasome Proto-Oncogene Proteins c-cbl - metabolism Receptors, Antigen, T-Cell - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis T cell receptors T-cell receptor T-Lymphocytes - metabolism Ubiquitination Wiskott-Aldrich syndrome Wiskott-Aldrich syndrome protein Wiskott-Aldrich Syndrome Protein - genetics Wiskott-Aldrich Syndrome Protein - metabolism
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