Cytochrome P450 system expression and DNA adduct formation in the liver of Zacco platypus following waterborne Benzo(a)pyrene exposure: implications for biomarker determination

Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon that causes mutations and tumor formation. Zacco platypus is a sentinel species that is suitable for monitoring aquatic environments. We studied cytochrome P450 system (CYP system) expression and DNA adduct formation in the liver of Z. platyp...

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Veröffentlicht in:	Environmental toxicology 2014-09, Vol.29 (9), p.1032-1042
Hauptverfasser:	Lee, Jin Wuk, Kim, Yong Hwa, Yoon, Seokjoo, Lee, Sung Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	acute toxicity Animals aquatic environment benzo(a)pyrene Benzo(a)pyrene - toxicity biomarkers Biomarkers - metabolism Cyprinidae cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P450 system DNA DNA adduct DNA Adducts - metabolism Environmental Exposure Environmental Monitoring - methods gene expression hepatosomatic index indicator species liver messenger RNA Microsomes, Liver - drug effects Microsomes, Liver - enzymology Microsomes, Liver - metabolism monitoring mutation Platypus polycyclic aromatic hydrocarbons protein synthesis risk risk assessment RNA, Messenger - metabolism Water Pollutants, Chemical - toxicity Zacco platypus
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