Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms

Both interleukin-12 (IL 12) anti tumor necrosis factor alpha (TNF-alpha) are produced earls in intracellular bacterial infection. Depletion of either IL- 12 or TFN-alpha by a single injection of specific antibody 4 h before the injection of Brucella abortus 19 fed to the exacerbation of infection 2...

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Veröffentlicht in:	Infection and Immunity 1996-07, Vol.64 (7), p.2782-2786
Hauptverfasser:	Zhan, Y, Liu, Z, Cheers, C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV animal diseases animal health Animals Antibodies, Monoclonal - administration & dosage Bacterial diseases bacterial infections Biological and medical sciences Brucella abortus Brucella abortus - immunology Brucella abortus - isolation & purification Brucella abortus - pathogenicity Brucellosis - immunology Brucellosis - microbiology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Colony Count, Microbial Experimental bacterial diseases and models Female Immunity, Cellular Infectious diseases Inflammation - etiology Inflammation - prevention & control Interferon-gamma - biosynthesis Interleukin-12 - antagonists & inhibitors Interleukin-12 - metabolism Male Medical sciences Mice Mice, Inbred CBA Spleen - immunology Time Factors Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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