Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, the relationship between periostin and the development of airflow limitation, a functional consequence of airwa...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2013-08, Vol.132 (2), p.305-312.e3
Hauptverfasser:	Kanemitsu, Yoshihiro, MD, Matsumoto, Hisako, MD, PhD, Izuhara, Kenji, MD, PhD, Tohda, Yuji, MD, PhD, Kita, Hideo, MD, PhD, Horiguchi, Takahiko, MD, PhD, Kuwabara, Kazunobu, MD, PhD, Tomii, Keisuke, MD, PhD, Otsuka, Kojiro, MD, PhD, Fujimura, Masaki, MD, PhD, Ohkura, Noriyuki, MD, PhD, Tomita, Katsuyuki, MD, PhD, Yokoyama, Akihito, MD, PhD, Ohnishi, Hiroshi, MD, PhD, Nakano, Yasutaka, MD, PhD, Oguma, Tetsuya, MD, PhD, Hozawa, Soichiro, MD, PhD, Nagasaki, Tadao, MD, Ito, Isao, MD, PhD, Oguma, Tsuyoshi, MD, Inoue, Hideki, MD, Tajiri, Tomoko, MD, Iwata, Toshiyuki, MD, Izuhara, Yumi, MD, Ono, Junya, BS, Ohta, Shoichiro, MD, PhD, Tamari, Mayumi, MD, PhD, Hirota, Tomomitsu, DDS, PhD, Yokoyama, Tetsuji, MD, PhD, Niimi, Akio, MD, PhD, Mishima, Michiaki, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Age Aged Airway management Airway Remodeling - drug effects Allergy and Immunology Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - therapeutic use Asthma Asthma - drug therapy Asthma - genetics Asthma - physiopathology Biological and medical sciences Biomarkers Biomarkers - metabolism Cell Adhesion Molecules - blood Cell Adhesion Molecules - genetics Deoxyribonucleic acid Disease DNA Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Haplotypes Humans inhaled corticosteroids Lung - physiopathology lung function decline Male Medical sciences Middle Aged Multivariate analysis periostin Polymorphism, Genetic POSTN gene polymorphism Proteins Questionnaires Respiratory Function Tests Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis sinusitis treatment step Up-Regulation
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