Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice
Schistosomiasis is a disease with a strong genetic component influenced by socioeconomic and ecological factors. Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to...
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| Veröffentlicht in: | Acta parasitologica 2014-09, Vol.59 (3), p.529-539 |
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| creator | del Villar, Luis Pérez Vicente, Belén Blanco-Gómez, Adrian Castellanos, Andrés Pérez-Losada, Jesús Muro, Antonio |
| description | Schistosomiasis is a disease with a strong genetic component influenced by socioeconomic and ecological factors. Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to the disease. The study of experimental infections in
inbred
mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to
S. mansoni
infection. |
| doi_str_mv | 10.2478/s11686-014-0277-4 |
| format | Article |
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inbred
mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to
S. mansoni
infection.</description><identifier>ISSN: 1230-2821</identifier><identifier>ISSN: 1896-1851</identifier><identifier>EISSN: 1896-1851</identifier><identifier>DOI: 10.2478/s11686-014-0277-4</identifier><identifier>PMID: 25119369</identifier><language>eng</language><publisher>Heidelberg: Versita</publisher><subject>Animal Systematics/Taxonomy/Biogeography ; Animals ; Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Chimera ; Disease ; Disease Susceptibility ; Ecology ; Eggs ; experimental crosses ; F1B6CBA hybrid ; Female ; Granulomas ; Hematology ; immunophenotypes ; Immunophenotyping ; Infections ; Laboratory animals ; Liver ; Lymphocytes ; Male ; Medical Microbiology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Microbiology ; Neutrophils ; Original Paper ; Parasitology ; Phenotype ; S. mansoni infection ; Schistosoma mansoni ; Schistosoma mansoni - immunology ; Schistosomiasis mansoni - immunology ; Schistosomiasis mansoni - pathology ; Schistosomiasis susceptibility</subject><ispartof>Acta parasitologica, 2014-09, Vol.59 (3), p.529-539</ispartof><rights>Versita Warsaw and Springer-Verlag Wien 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c456t-47fc92a5bdcebaccf31cae31103c5f6118a0d38b199bebd653805710137e7b2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.2478/s11686-014-0277-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.2478/s11686-014-0277-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27925,27926,41489,42558,51320</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25119369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>del Villar, Luis Pérez</creatorcontrib><creatorcontrib>Vicente, Belén</creatorcontrib><creatorcontrib>Blanco-Gómez, Adrian</creatorcontrib><creatorcontrib>Castellanos, Andrés</creatorcontrib><creatorcontrib>Pérez-Losada, Jesús</creatorcontrib><creatorcontrib>Muro, Antonio</creatorcontrib><title>Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice</title><title>Acta parasitologica</title><addtitle>Acta Parasit</addtitle><addtitle>Acta Parasitol</addtitle><description>Schistosomiasis is a disease with a strong genetic component influenced by socioeconomic and ecological factors. Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to the disease. The study of experimental infections in
inbred
mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to
S. mansoni
infection.</description><subject>Animal Systematics/Taxonomy/Biogeography</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Chimera</subject><subject>Disease</subject><subject>Disease Susceptibility</subject><subject>Ecology</subject><subject>Eggs</subject><subject>experimental crosses</subject><subject>F1B6CBA hybrid</subject><subject>Female</subject><subject>Granulomas</subject><subject>Hematology</subject><subject>immunophenotypes</subject><subject>Immunophenotyping</subject><subject>Infections</subject><subject>Laboratory animals</subject><subject>Liver</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Microbiology</subject><subject>Neutrophils</subject><subject>Original Paper</subject><subject>Parasitology</subject><subject>Phenotype</subject><subject>S. mansoni infection</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Schistosomiasis mansoni - pathology</subject><subject>Schistosomiasis susceptibility</subject><issn>1230-2821</issn><issn>1896-1851</issn><issn>1896-1851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rFTEYhYMotlZ_gBsZcONmNG8y-ZiVtJdWCwUXreuQZDK3KTPJOMlU5t8316kigtBVzuI5D284CL0F_JE0Qn5KAFzyGkNTYyJE3TxDxyBbXoNk8LxkQnFNJIEj9CqlO4wbLqV8iY4IA2gpb4-RuexcyL5ffdhX060LMa-TS5UP93G4d10JVVqSdVP2xg8-r1WO1bW99SnHFEddjTqkGHwBe2ezj-FQuYAzvjs7rUZv3Wv0otdDcm8e3xP0_eL8Zve1vvr25XJ3elXbhvFcN6K3LdHMdNYZbW1PwWpHATC1rOcAUuOOSgNta5zpOKMSMwEYqHDCEE1P0IfNO83xx-JSVqMvhw-DDi4uSQHjGDAXDJ6AMipwI4AW9P0_6F1c5lA-8osiLRUNKRRslJ1jSrPr1TT7Uc-rAqwOW6ltK1W2UoetVFM67x7Nixld96fxe5wCfN6An3rIbu7cfl7WEv664H9y1lJGDgayGVKRh_2TqvQBhY-yyA</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>del Villar, Luis Pérez</creator><creator>Vicente, Belén</creator><creator>Blanco-Gómez, Adrian</creator><creator>Castellanos, Andrés</creator><creator>Pérez-Losada, Jesús</creator><creator>Muro, Antonio</creator><general>Versita</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice</title><author>del Villar, Luis Pérez ; Vicente, Belén ; Blanco-Gómez, Adrian ; Castellanos, Andrés ; Pérez-Losada, Jesús ; Muro, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-47fc92a5bdcebaccf31cae31103c5f6118a0d38b199bebd653805710137e7b2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animal Systematics/Taxonomy/Biogeography</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Chimera</topic><topic>Disease</topic><topic>Disease Susceptibility</topic><topic>Ecology</topic><topic>Eggs</topic><topic>experimental crosses</topic><topic>F1B6CBA hybrid</topic><topic>Female</topic><topic>Granulomas</topic><topic>Hematology</topic><topic>immunophenotypes</topic><topic>Immunophenotyping</topic><topic>Infections</topic><topic>Laboratory animals</topic><topic>Liver</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Microbiology</topic><topic>Neutrophils</topic><topic>Original Paper</topic><topic>Parasitology</topic><topic>Phenotype</topic><topic>S. mansoni infection</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - 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Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to the disease. The study of experimental infections in
inbred
mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to
S. mansoni
infection.</abstract><cop>Heidelberg</cop><pub>Versita</pub><pmid>25119369</pmid><doi>10.2478/s11686-014-0277-4</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta parasitologica, 2014-09, Vol.59 (3), p.529-539 |
| issn | 1230-2821 1896-1851 1896-1851 |
| language | eng |
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| subjects | Animal Systematics/Taxonomy/Biogeography Animals Antibodies Biomedical and Life Sciences Biomedicine Blood Chimera Disease Disease Susceptibility Ecology Eggs experimental crosses F1B6CBA hybrid Female Granulomas Hematology immunophenotypes Immunophenotyping Infections Laboratory animals Liver Lymphocytes Male Medical Microbiology Mice Mice, Inbred C57BL Mice, Inbred CBA Microbiology Neutrophils Original Paper Parasitology Phenotype S. mansoni infection Schistosoma mansoni Schistosoma mansoni - immunology Schistosomiasis mansoni - immunology Schistosomiasis mansoni - pathology Schistosomiasis susceptibility |
| title | Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice |
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