Natural killer cells in patients with allergic diseases
Natural killer (NK) cells not only exert cytotoxic activity against tumor cells or infected cells but also act to regulate the function of other immune cells through secretion of cytokines and chemokines or cell contact–dependent mechanisms. NK cells are able to polarize in vitro into 2 functional d...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2013-09, Vol.132 (3), p.527-535 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Deniz, Günnur, PhD van de Veen, Willem, MSc Akdis, Mübeccel, MD, PhD |
| description | Natural killer (NK) cells not only exert cytotoxic activity against tumor cells or infected cells but also act to regulate the function of other immune cells through secretion of cytokines and chemokines or cell contact–dependent mechanisms. NK cells are able to polarize in vitro into 2 functional distinct subsets, NK1 or NK2 cells, which are analogous to the T-cell subsets TH 1 or TH 2. In addition, a regulatory NK cell subset has been described that secretes IL-10, shows antigen-specific T-cell suppression, and suppresses IgE production. Although it has been demonstrated that NK cells play important roles in autoimmunity, cancer, transplantation, and pregnancy, the role of NK cells in allergy has not been extensively discussed. This review aims to discuss our understanding of NK cells and NK cell subsets in allergic inflammation and IgE regulation. |
| doi_str_mv | 10.1016/j.jaci.2013.07.030 |
| format | Article |
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NK cells are able to polarize in vitro into 2 functional distinct subsets, NK1 or NK2 cells, which are analogous to the T-cell subsets TH 1 or TH 2. In addition, a regulatory NK cell subset has been described that secretes IL-10, shows antigen-specific T-cell suppression, and suppresses IgE production. Although it has been demonstrated that NK cells play important roles in autoimmunity, cancer, transplantation, and pregnancy, the role of NK cells in allergy has not been extensively discussed. This review aims to discuss our understanding of NK cells and NK cell subsets in allergic inflammation and IgE regulation.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.07.030</identifier><identifier>PMID: 23993354</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>allergic inflammation ; Allergy and Immunology ; Animals ; Antigens ; Biological and medical sciences ; Cell adhesion & migration ; Chemokines ; Cytokines ; Cytotoxicity ; Disease ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Human subjects ; Humans ; Hypersensitivity - immunology ; Immune system ; Immunologic Memory ; Immunopathology ; Killer Cells, Natural - immunology ; Ligands ; Lymphocyte Subsets - immunology ; Lymphocytes ; Medical sciences ; Natural killer cells ; NK1 ; NK2 ; NK22 ; Psoriasis ; Rheumatoid arthritis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Viral infections</subject><ispartof>Journal of allergy and clinical immunology, 2013-09, Vol.132 (3), p.527-535</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-9533815a8b8f97aea0f829fc0fb97cdf591d9b5201618b7fefd783e4b76fe873</citedby><cites>FETCH-LOGICAL-c502t-9533815a8b8f97aea0f829fc0fb97cdf591d9b5201618b7fefd783e4b76fe873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2013.07.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27720463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23993354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deniz, Günnur, PhD</creatorcontrib><creatorcontrib>van de Veen, Willem, MSc</creatorcontrib><creatorcontrib>Akdis, Mübeccel, MD, PhD</creatorcontrib><title>Natural killer cells in patients with allergic diseases</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Natural killer (NK) cells not only exert cytotoxic activity against tumor cells or infected cells but also act to regulate the function of other immune cells through secretion of cytokines and chemokines or cell contact–dependent mechanisms. NK cells are able to polarize in vitro into 2 functional distinct subsets, NK1 or NK2 cells, which are analogous to the T-cell subsets TH 1 or TH 2. In addition, a regulatory NK cell subset has been described that secretes IL-10, shows antigen-specific T-cell suppression, and suppresses IgE production. Although it has been demonstrated that NK cells play important roles in autoimmunity, cancer, transplantation, and pregnancy, the role of NK cells in allergy has not been extensively discussed. This review aims to discuss our understanding of NK cells and NK cell subsets in allergic inflammation and IgE regulation.</description><subject>allergic inflammation</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Cell adhesion & migration</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Disease</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Immune system</subject><subject>Immunologic Memory</subject><subject>Immunopathology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Ligands</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Lymphocytes</subject><subject>Medical sciences</subject><subject>Natural killer cells</subject><subject>NK1</subject><subject>NK2</subject><subject>NK22</subject><subject>Psoriasis</subject><subject>Rheumatoid arthritis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Viral infections</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoMo7jj6BzxIgwheuq0knS-QBVn8gkUP7sFbSKcrmt6enjHpVvbfm2ZGF_agp1Dkqaq36i1CnlJoKFD5amgG52PDgPIGVAMc7pENBaNqqZm4TzYAhtZSteaMPMp5gBJzbR6SM8aN4Vy0G6I-uXlJbqyu4zhiqjyOY67iVB3cHHGac_Urzt8rt35-i77qY0aXMT8mD4IbMz45vVty9e7t1cWH-vLz-48Xby5rL4DNtRGcayqc7nQwyqGDoJkJHkJnlO-DMLQ3nSgjSKo7FTD0SnNsOyUDasW35OWx7CHtfyyYZ7uLedXoJtwv2VIhgYIE0f4fbZmRrWDSFPT5HXTYL2kqc5SCohWa6aJ7S9iR8mmfc8JgDynuXLqxFOxqgB3saoBdDbCgbDGgJD07lV66HfZ_U_5svAAvToDL3o0hucnHfMspxaCVa_fXRw7Ldn9GTDb7YojHPib0s-338d86zu-k-zFOsXS8xhvMt_PazCzYL-uprJdCOdCyg6_8NyzXtmM</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Deniz, Günnur, PhD</creator><creator>van de Veen, Willem, MSc</creator><creator>Akdis, Mübeccel, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Natural killer cells in patients with allergic diseases</title><author>Deniz, Günnur, PhD ; van de Veen, Willem, MSc ; Akdis, Mübeccel, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-9533815a8b8f97aea0f829fc0fb97cdf591d9b5201618b7fefd783e4b76fe873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>allergic inflammation</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Cell adhesion & migration</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Disease</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Immune system</topic><topic>Immunologic Memory</topic><topic>Immunopathology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Ligands</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Lymphocytes</topic><topic>Medical sciences</topic><topic>Natural killer cells</topic><topic>NK1</topic><topic>NK2</topic><topic>NK22</topic><topic>Psoriasis</topic><topic>Rheumatoid arthritis</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deniz, Günnur, PhD</creatorcontrib><creatorcontrib>van de Veen, Willem, MSc</creatorcontrib><creatorcontrib>Akdis, Mübeccel, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deniz, Günnur, PhD</au><au>van de Veen, Willem, MSc</au><au>Akdis, Mübeccel, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural killer cells in patients with allergic diseases</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>132</volume><issue>3</issue><spage>527</spage><epage>535</epage><pages>527-535</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Natural killer (NK) cells not only exert cytotoxic activity against tumor cells or infected cells but also act to regulate the function of other immune cells through secretion of cytokines and chemokines or cell contact–dependent mechanisms. NK cells are able to polarize in vitro into 2 functional distinct subsets, NK1 or NK2 cells, which are analogous to the T-cell subsets TH 1 or TH 2. In addition, a regulatory NK cell subset has been described that secretes IL-10, shows antigen-specific T-cell suppression, and suppresses IgE production. Although it has been demonstrated that NK cells play important roles in autoimmunity, cancer, transplantation, and pregnancy, the role of NK cells in allergy has not been extensively discussed. This review aims to discuss our understanding of NK cells and NK cell subsets in allergic inflammation and IgE regulation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23993354</pmid><doi>10.1016/j.jaci.2013.07.030</doi><tpages>9</tpages></addata></record> |
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| subjects | allergic inflammation Allergy and Immunology Animals Antigens Biological and medical sciences Cell adhesion & migration Chemokines Cytokines Cytotoxicity Disease Fundamental and applied biological sciences. Psychology Fundamental immunology Human subjects Humans Hypersensitivity - immunology Immune system Immunologic Memory Immunopathology Killer Cells, Natural - immunology Ligands Lymphocyte Subsets - immunology Lymphocytes Medical sciences Natural killer cells NK1 NK2 NK22 Psoriasis Rheumatoid arthritis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Viral infections |
| title | Natural killer cells in patients with allergic diseases |
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