Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

GS-9620 is a novel oral agonist of Toll-like receptor 7 (TLR7) in development for the treatment of chronic viral hepatitis. TLR7 is a highly conserved innate immune receptor expressed primarily on plasmacytoid dendritic cells and B lymphocytes. The aim of this double-blind, placebo-controlled, singl...

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Veröffentlicht in:	Antiviral therapy 2013-01, Vol.18 (3), p.409-418
Hauptverfasser:	LOPATIN, Uri, WOLFGANG, Grushenka, TUMAS, Daniel, FREY, Christian R, OHMSTEDE, Carol, HESSELGESSER, Joseph, KEARNEY, Brian, MOOREHEAD, Lisa, SUBRAMANIAN, G. Mani, MCHUTCHISON, John G
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - pharmacokinetics Biological and medical sciences Cytokines - biosynthesis Female Humans Male Medical sciences Pharmacology. Drug treatments Pteridines - administration & dosage Pteridines - adverse effects Pteridines - pharmacokinetics Toll-Like Receptor 7 - agonists Ubiquitins - biosynthesis Young Adult
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