Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

Summary Background Identification of robust biomarkers of malignancy and methods to establish disease progression is a major goal in paediatric neuro-oncology. We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours....

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Veröffentlicht in:	The lancet oncology 2013-05, Vol.14 (6), p.534-542
Hauptverfasser:	Castelo-Branco, Pedro, PhD, Choufani, Sanaa, PhD, Mack, Stephen, BSc, Gallagher, Denis, PhD, Zhang, Cindy, MSc, Lipman, Tatiana, MSc, Zhukova, Nataliya, MD, Walker, Erin J, PhD, Martin, Dianna, PhD, Merino, Diana, MSc, Wasserman, Jonathan D, MD, Elizabeth, Cynthia, MSc, Alon, Noa, BSc, Zhang, Libo, PhD, Hovestadt, Volker, MSc, Kool, Marcel, PhD, Jones, David TW, PhD, Zadeh, Gelareh, MD, Croul, Sidney, Prof, Hawkins, Cynthia, MD, Hitzler, Johann, MD, Wang, Jean CY, MD, Baruchel, Sylvain, Prof, Dirks, Peter B, Prof, Malkin, David, Prof, Pfister, Stefan, MD, Taylor, Michael D, MD, Weksberg, Rosanna, Prof, Tabori, Uri, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Biomarkers Biomarkers, Tumor - genetics Brain cancer Brain Neoplasms - enzymology Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology CpG Islands Disease-Free Survival DNA Methylation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Genome-Wide Association Study Germany Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate Medical research Multivariate Analysis Neoplasm Grading Ontario Phenotype Promoter Regions, Genetic Proportional Hazards Models Real-Time Polymerase Chain Reaction Reproducibility of Results Retrospective Studies Stem cells Telomerase - genetics Time Factors Transcription Initiation Site
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