Molecular mechanism of bacterial persistence by HipA

HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits cell growth by the phosphorylation of the essential translation factor EF-Tu. Here, we provide evidence that EF...

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Veröffentlicht in:	Molecular cell 2013-10, Vol.52 (2), p.248-254
Hauptverfasser:	Germain, Elsa, Castro-Roa, Daniel, Zenkin, Nikolay, Gerdes, Kenn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aminoacylation Anti-Bacterial Agents - pharmacology Binding Sites - genetics Drug Tolerance Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Glutamate-tRNA Ligase - chemistry Glutamate-tRNA Ligase - genetics Glutamate-tRNA Ligase - metabolism Guanosine Pentaphosphate - metabolism Models, Genetic Models, Molecular Mutation Peptide Elongation Factor Tu - genetics Peptide Elongation Factor Tu - metabolism Phosphorylation Protein Biosynthesis Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein Structure, Tertiary Ribosomes - genetics Ribosomes - metabolism RNA, Transfer, Glu - genetics RNA, Transfer, Glu - metabolism Serine - chemistry Serine - genetics Serine - metabolism
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